Abstract
We assessed the clinical utility of measuring thyrotropin (TSH) in serum by immunoradiometry and of measuring total thyroxin (TT4), total triiodothyronine (TT3), free thyroxin (FT4), and free triiodothyronine (FT3). We used a group of 110 healthy volunteers, 45 ill hypoalbuminemic patients, and 42 ill normoalbuminemic patients. In addition, the free thyroxin index (FTI) and TT4:thyroxin-binding globulin (TBG) ratio were also calculated. The hypoalbuminemic group had significantly lower FT4, FT3, TT4, TT3, and FTI concentrations, but only FT3 and TT3 were significantly lower in the ill normoalbuminemic group as compared with controls. We found significant correlation between FT4 and albumin (r = 0.372, P < 0.001) and FT3 and albumin (r = 0.465, P < 0.001). TSH concentrations were undetectable in two of 45 hypoalbuminemic patients, significantly higher in the rest. The TT4/TBG ratio was the only parameter of thyroid function that remained unchanged in the ill patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1445-1447 |
| Number of pages | 3 |
| Journal | Clinical Chemistry |
| Volume | 33 |
| Issue number | 8 |
| State | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
Thyroid function in hospitalized patients : Effect of illness and serum albumin concentrations. / Desai, R. K.; Jialal, I.; Aitchison, J. M.; Joubert, S. M.
In: Clinical Chemistry, Vol. 33, No. 8, 1987, p. 1445-1447.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thyroid function in hospitalized patients
T2 - Effect of illness and serum albumin concentrations
AU - Desai, R. K.
AU - Jialal, I.
AU - Aitchison, J. M.
AU - Joubert, S. M.
PY - 1987
Y1 - 1987
N2 - We assessed the clinical utility of measuring thyrotropin (TSH) in serum by immunoradiometry and of measuring total thyroxin (TT4), total triiodothyronine (TT3), free thyroxin (FT4), and free triiodothyronine (FT3). We used a group of 110 healthy volunteers, 45 ill hypoalbuminemic patients, and 42 ill normoalbuminemic patients. In addition, the free thyroxin index (FTI) and TT4:thyroxin-binding globulin (TBG) ratio were also calculated. The hypoalbuminemic group had significantly lower FT4, FT3, TT4, TT3, and FTI concentrations, but only FT3 and TT3 were significantly lower in the ill normoalbuminemic group as compared with controls. We found significant correlation between FT4 and albumin (r = 0.372, P < 0.001) and FT3 and albumin (r = 0.465, P < 0.001). TSH concentrations were undetectable in two of 45 hypoalbuminemic patients, significantly higher in the rest. The TT4/TBG ratio was the only parameter of thyroid function that remained unchanged in the ill patients.
AB - We assessed the clinical utility of measuring thyrotropin (TSH) in serum by immunoradiometry and of measuring total thyroxin (TT4), total triiodothyronine (TT3), free thyroxin (FT4), and free triiodothyronine (FT3). We used a group of 110 healthy volunteers, 45 ill hypoalbuminemic patients, and 42 ill normoalbuminemic patients. In addition, the free thyroxin index (FTI) and TT4:thyroxin-binding globulin (TBG) ratio were also calculated. The hypoalbuminemic group had significantly lower FT4, FT3, TT4, TT3, and FTI concentrations, but only FT3 and TT3 were significantly lower in the ill normoalbuminemic group as compared with controls. We found significant correlation between FT4 and albumin (r = 0.372, P < 0.001) and FT3 and albumin (r = 0.465, P < 0.001). TSH concentrations were undetectable in two of 45 hypoalbuminemic patients, significantly higher in the rest. The TT4/TBG ratio was the only parameter of thyroid function that remained unchanged in the ill patients.
UR - http://www.scopus.com/inward/record.url?scp=0023630298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023630298&partnerID=8YFLogxK
M3 - Article
C2 - 3111754
AN - SCOPUS:0023630298
VL - 33
SP - 1445
EP - 1447
JO - Clinical Chemistry
JF - Clinical Chemistry
SN - 0009-9147
IS - 8
ER -