Thymoma-associated multiorgan autoimmunity: A graft-versus-host-like disease

Akhil Wadhera, Emanual Michael Maverakis, Nicholas Mitsiades, Primo N Lara, Maxwell A Fung, Peter J. Lynch

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50 Scopus citations

Abstract

Graft-versus-host disease (GVHD) is a T cell-mediated disease seen most commonly after hematopoietic stem cell transplantation. Rarely, a GVHD-like disease can be seen in patients with malignant thymoma. We describe a 50-year-old man with malignant thymoma who developed skin, liver, and intestinal manifestations similar to that seen in GVHD. We also review other reported cases of GVHD-like manifestations in the setting of thymoma and propose "thymoma-associated multiorgan autoimmunity" as a name for this novel disease. Specifically, thymoma-associated multiorgan autoimmunity is defined as a disease of the liver, intestine, or skin, which on histopathology resembles GVHD but is seen in the setting of malignant thymoma and not after hematopoietic stem cell transplantation.

Original languageEnglish (US)
Pages (from-to)683-689
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume57
Issue number4
DOIs
StatePublished - Oct 2007

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ASJC Scopus subject areas

  • Dermatology

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