Thymoma-associated multiorgan autoimmunity: A graft-versus-host-like disease

Akhil Wadhera, Emanual Michael Maverakis, Nicholas Mitsiades, Primo N Lara, Maxwell A Fung, Peter J. Lynch

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Graft-versus-host disease (GVHD) is a T cell-mediated disease seen most commonly after hematopoietic stem cell transplantation. Rarely, a GVHD-like disease can be seen in patients with malignant thymoma. We describe a 50-year-old man with malignant thymoma who developed skin, liver, and intestinal manifestations similar to that seen in GVHD. We also review other reported cases of GVHD-like manifestations in the setting of thymoma and propose "thymoma-associated multiorgan autoimmunity" as a name for this novel disease. Specifically, thymoma-associated multiorgan autoimmunity is defined as a disease of the liver, intestine, or skin, which on histopathology resembles GVHD but is seen in the setting of malignant thymoma and not after hematopoietic stem cell transplantation.

Original languageEnglish (US)
Pages (from-to)683-689
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume57
Issue number4
DOIs
StatePublished - Oct 2007

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Thymoma
Graft vs Host Disease
Autoimmunity
Hematopoietic Stem Cell Transplantation
Skin Diseases
Intestines
Names
Liver Diseases
T-Lymphocytes
Skin
Liver

ASJC Scopus subject areas

  • Dermatology

Cite this

Thymoma-associated multiorgan autoimmunity : A graft-versus-host-like disease. / Wadhera, Akhil; Maverakis, Emanual Michael; Mitsiades, Nicholas; Lara, Primo N; Fung, Maxwell A; Lynch, Peter J.

In: Journal of the American Academy of Dermatology, Vol. 57, No. 4, 10.2007, p. 683-689.

Research output: Contribution to journalArticle

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