Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ

Kirk D C Jensen, Xiaoqin Su, Sunny Shin, Luke Li, Sawsan Youssef, Sho Yamasaki, Lawrence Steinman, Takashi Saito, Richard M. Locksley, Mark M. Davis, Nicole Baumgarth, Yueh hsiu Chien

Research output: Contribution to journalArticle

305 Citations (Scopus)

Abstract

γδ T cells uniquely contribute to host immune defense, but how this is accomplished remains unclear. Here, we analyzed the nonclassical major histocompatibility complex class I T10 and T22-specific γδ T cells in mice and found that encountering antigen in the thymus was neither required nor inhibitory for their development. But when triggered through the T cell receptor, ligand-naive lymphoid-γδ T cells produced IL-17, whereas ligand-experienced cells made IFN-γ. Immediately after immunization, a large fraction of IL-17+ γδ T cells were found in the draining lymph nodes days before the appearance of antigen-specific IL-17+ αβ T cells. Thus, thymic selection determines the effector fate of γδ T cells rather than constrains their antigen specificities. The swift IL-17 response mounted by antigen-naive γδ T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens.

Original languageEnglish (US)
Pages (from-to)90-100
Number of pages11
JournalImmunity
Volume29
Issue number1
DOIs
StatePublished - Jul 18 2008

Fingerprint

Interleukin-17
Interferons
T-Lymphocytes
Antigens
Ligands
T-Cell Antigen Receptor
Major Histocompatibility Complex
Thymus Gland
Immunization
Lymph Nodes
Lymphocytes

Keywords

  • CELLIMMUNO
  • MOLIMMUNO

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Thymic Selection Determines γδ T Cell Effector Fate : Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ. / Jensen, Kirk D C; Su, Xiaoqin; Shin, Sunny; Li, Luke; Youssef, Sawsan; Yamasaki, Sho; Steinman, Lawrence; Saito, Takashi; Locksley, Richard M.; Davis, Mark M.; Baumgarth, Nicole; Chien, Yueh hsiu.

In: Immunity, Vol. 29, No. 1, 18.07.2008, p. 90-100.

Research output: Contribution to journalArticle

Jensen, KDC, Su, X, Shin, S, Li, L, Youssef, S, Yamasaki, S, Steinman, L, Saito, T, Locksley, RM, Davis, MM, Baumgarth, N & Chien, YH 2008, 'Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ', Immunity, vol. 29, no. 1, pp. 90-100. https://doi.org/10.1016/j.immuni.2008.04.022
Jensen, Kirk D C ; Su, Xiaoqin ; Shin, Sunny ; Li, Luke ; Youssef, Sawsan ; Yamasaki, Sho ; Steinman, Lawrence ; Saito, Takashi ; Locksley, Richard M. ; Davis, Mark M. ; Baumgarth, Nicole ; Chien, Yueh hsiu. / Thymic Selection Determines γδ T Cell Effector Fate : Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ. In: Immunity. 2008 ; Vol. 29, No. 1. pp. 90-100.
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