Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ

Kirk D C Jensen, Xiaoqin Su, Sunny Shin, Luke Li, Sawsan Youssef, Sho Yamasaki, Lawrence Steinman, Takashi Saito, Richard M. Locksley, Mark M. Davis, Nicole Baumgarth, Yueh hsiu Chien

Research output: Contribution to journalArticle

329 Scopus citations

Abstract

γδ T cells uniquely contribute to host immune defense, but how this is accomplished remains unclear. Here, we analyzed the nonclassical major histocompatibility complex class I T10 and T22-specific γδ T cells in mice and found that encountering antigen in the thymus was neither required nor inhibitory for their development. But when triggered through the T cell receptor, ligand-naive lymphoid-γδ T cells produced IL-17, whereas ligand-experienced cells made IFN-γ. Immediately after immunization, a large fraction of IL-17+ γδ T cells were found in the draining lymph nodes days before the appearance of antigen-specific IL-17+ αβ T cells. Thus, thymic selection determines the effector fate of γδ T cells rather than constrains their antigen specificities. The swift IL-17 response mounted by antigen-naive γδ T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens.

Original languageEnglish (US)
Pages (from-to)90-100
Number of pages11
JournalImmunity
Volume29
Issue number1
DOIs
StatePublished - Jul 18 2008

Keywords

  • CELLIMMUNO
  • MOLIMMUNO

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

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    Jensen, K. D. C., Su, X., Shin, S., Li, L., Youssef, S., Yamasaki, S., Steinman, L., Saito, T., Locksley, R. M., Davis, M. M., Baumgarth, N., & Chien, Y. H. (2008). Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ. Immunity, 29(1), 90-100. https://doi.org/10.1016/j.immuni.2008.04.022