Thymic Carcinoma Presenting as Cranial Metastasis with Intradural and Extracranial Extension: Case Report

Yoji Tamura, Toshihiko Kuroiwa, Atsushi Doi, Kyong Yob Min, Laligam N. Sekhar, Dinko Stimac, Vinko V. Dolenc, Griffith R. Harsh IV

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

OBJECTIVE AND IMPORTANCE: Thymic carcinoma is an uncommon malignant tumor that is different from thymoma. Cranial and brain metastases from this tumor are extremely rare. We report a thymic carcinoma with cranial metastasis and discuss the behavior of this tumor. CLINICAL PRESENTATION: A 50-year-old man presented with headache and a palpable scalp tumor. Computed tomographic scans and magnetic resonance images revealed an osteolytic tumor with intradural and extracranial extension in the right occipital bone. INTERVENTION: After gross total resection and histological diagnosis, further investigation revealed a primary thymic tumor in the anterior upper mediastinum and liver metastases. The patient received multiple-cycle chemotherapy (cisplatin and gemcitabine) for primary and metastatic lesions. CONCLUSION: Thymic carcinoma has a poor prognosis because of a high degree of malignancy, early metastasis, and delayed diagnosis. Thus, treatment of a patient with this tumor calls for prompt diagnosis, surgical treatment, and optimal adjuvant therapy.

Original languageEnglish (US)
Pages (from-to)209-212
Number of pages4
JournalNeurosurgery
Volume54
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

Keywords

  • Cranium
  • Metastasis
  • Skull
  • Thymic carcinoma

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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