Abstract
While the most common clinical feature of nephrotic syndrome is generalized edema, patients are at risk of developing other problems, such as bacterial infections, electrolyte abnormalities, and venous thromboses. Adults with membranous nephropathy appear to be at the greatest risk for developing thromboses, especially renal vein thrombosis. However, the same is not true for children with membranous nephropathy. A review of pediatric membranous nephropathy stated that renal vein thrombosis is unrecorded in childhood-onset membranous nephropathy. We present our experience in managing two children with idiopathic membranous nephropathy who developed venous thromboses. To our knowledge, this is the first report of pediatric patients with membranous nephropathy to develop a thromboembolic complication without evidence of predisposing factors or coagulation abnormalities. This report emphasizes the need for appropriate evaluation of patients with membranous nephropathy who develop signs and symptoms suggestive of arterial or venous occlusion in order to avoid missing this potentially life-threatening medical complication.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1298-1300 |
| Number of pages | 3 |
| Journal | Pediatric Nephrology |
| Volume | 18 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2003 |
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Keywords
- Inferior vena cava thrombus
- Membranous nephropathy
- Nephrotic syndrome
- Renal vein thrombosis
- Thromboembolism
ASJC Scopus subject areas
- Nephrology
- Pediatrics, Perinatology, and Child Health
Cite this
Thrombotic complications in childhood-onset idiopathic membranous nephropathy. / Louis, Chrystal U.; Morgenstern, Bruce Z.; Butani, Lavjay.
In: Pediatric Nephrology, Vol. 18, No. 12, 12.2003, p. 1298-1300.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thrombotic complications in childhood-onset idiopathic membranous nephropathy
AU - Louis, Chrystal U.
AU - Morgenstern, Bruce Z.
AU - Butani, Lavjay
PY - 2003/12
Y1 - 2003/12
N2 - While the most common clinical feature of nephrotic syndrome is generalized edema, patients are at risk of developing other problems, such as bacterial infections, electrolyte abnormalities, and venous thromboses. Adults with membranous nephropathy appear to be at the greatest risk for developing thromboses, especially renal vein thrombosis. However, the same is not true for children with membranous nephropathy. A review of pediatric membranous nephropathy stated that renal vein thrombosis is unrecorded in childhood-onset membranous nephropathy. We present our experience in managing two children with idiopathic membranous nephropathy who developed venous thromboses. To our knowledge, this is the first report of pediatric patients with membranous nephropathy to develop a thromboembolic complication without evidence of predisposing factors or coagulation abnormalities. This report emphasizes the need for appropriate evaluation of patients with membranous nephropathy who develop signs and symptoms suggestive of arterial or venous occlusion in order to avoid missing this potentially life-threatening medical complication.
AB - While the most common clinical feature of nephrotic syndrome is generalized edema, patients are at risk of developing other problems, such as bacterial infections, electrolyte abnormalities, and venous thromboses. Adults with membranous nephropathy appear to be at the greatest risk for developing thromboses, especially renal vein thrombosis. However, the same is not true for children with membranous nephropathy. A review of pediatric membranous nephropathy stated that renal vein thrombosis is unrecorded in childhood-onset membranous nephropathy. We present our experience in managing two children with idiopathic membranous nephropathy who developed venous thromboses. To our knowledge, this is the first report of pediatric patients with membranous nephropathy to develop a thromboembolic complication without evidence of predisposing factors or coagulation abnormalities. This report emphasizes the need for appropriate evaluation of patients with membranous nephropathy who develop signs and symptoms suggestive of arterial or venous occlusion in order to avoid missing this potentially life-threatening medical complication.
KW - Inferior vena cava thrombus
KW - Membranous nephropathy
KW - Nephrotic syndrome
KW - Renal vein thrombosis
KW - Thromboembolism
UR - http://www.scopus.com/inward/record.url?scp=0346900919&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0346900919&partnerID=8YFLogxK
U2 - 10.1007/s00467-003-1320-0
DO - 10.1007/s00467-003-1320-0
M3 - Article
VL - 18
SP - 1298
EP - 1300
JO - Pediatric Nephrology
JF - Pediatric Nephrology
SN - 0931-041X
IS - 12
ER -