Thrombotic and hemorrhagic strokes complicating early therapy for childhood acute lymphoblastic leukemia

J. R. Priest, N. K C Ramsay, Richard E Latchaw, L. A. Lockman, D. K. Hasegawa, T. D. Coates, P. F. Coccia, J. R. Edson, M. E. Nesbit, W. Krivit

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Sudden cerebrovascular insults occurred during or immediately following remission induction therapy in 4 children with acute lymphoblastic leukemia. In 3, cerebral infarction was due to thrombosis. In the fourth, an intracerebral hematoma developed representing either frank hemorrhaging or a hemorrhagic infarction. None of the patients had central nervous system leukemia or extreme leukocytosis at the time of diagnosis. Symptoms were obtundation, hemiparesis, seizures, and headache. The induction chemotherapy included L-asparaginase which causes deficiencies of antithrombin, plasminogen, fibrinogen, and factors IX and XI. These hemostatic abnormalities may explain the thromboses and bleeding observed in these children.

Original languageEnglish (US)
Pages (from-to)1548-1554
Number of pages7
JournalCancer
Volume46
Issue number7
DOIs
StatePublished - 1980
Externally publishedYes

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Secondary Prevention
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thrombosis
Stroke
Factor XI
Remission Induction
Asparaginase
Induction Chemotherapy
Factor IX
Antithrombins
Plasminogen
Leukocytosis
Cerebral Infarction
Paresis
Hemostatics
Hematoma
Fibrinogen
Infarction
Headache
Leukemia

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Thrombotic and hemorrhagic strokes complicating early therapy for childhood acute lymphoblastic leukemia. / Priest, J. R.; Ramsay, N. K C; Latchaw, Richard E; Lockman, L. A.; Hasegawa, D. K.; Coates, T. D.; Coccia, P. F.; Edson, J. R.; Nesbit, M. E.; Krivit, W.

In: Cancer, Vol. 46, No. 7, 1980, p. 1548-1554.

Research output: Contribution to journalArticle

Priest, JR, Ramsay, NKC, Latchaw, RE, Lockman, LA, Hasegawa, DK, Coates, TD, Coccia, PF, Edson, JR, Nesbit, ME & Krivit, W 1980, 'Thrombotic and hemorrhagic strokes complicating early therapy for childhood acute lymphoblastic leukemia', Cancer, vol. 46, no. 7, pp. 1548-1554. https://doi.org/10.1002/1097-0142(19801001)46:7<1548::AID-CNCR2820460709>3.0.CO;2-7
Priest, J. R. ; Ramsay, N. K C ; Latchaw, Richard E ; Lockman, L. A. ; Hasegawa, D. K. ; Coates, T. D. ; Coccia, P. F. ; Edson, J. R. ; Nesbit, M. E. ; Krivit, W. / Thrombotic and hemorrhagic strokes complicating early therapy for childhood acute lymphoblastic leukemia. In: Cancer. 1980 ; Vol. 46, No. 7. pp. 1548-1554.
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AU - Coates, T. D.

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