Abstract
Dietary selection and intake of a threonine-imbalanced diet were evaluated after increasing the concentration of the dietary limiting amino acid in the prepyriform cortex. Selection against the threonine-imbalanced diet in favor of a protein-free diet was reversed when 2 or 4 nmol threonine was injected bilaterally into the prepyriform cortex. However, intake of the threonine-imbalanced diet was significantly increased only after injection of 2 nmol threonine. The reduced intake of the threonine-imbalanced diet, compared to the basal diet, after injection of 4 nmol threonine was not the result of an excess in the concentration of amino acid (or nitrogen) injected into the PPC because intake of the threonine-basal diet was not reduced when 4 nmol threonine was administered. Intake of the threonine-imbalanced diet was also increased after injection of 2 nmol threonine plus 2 nmol isoleucine but not after injections of 2 nmol isoleucine. The changes in food intake when an imbalanced diet is fed appear to be the result of at least two separable responses: recognition of a diet as having an amino acid imbalance, as indicated by dietary choice, and reduction in food intake. The results of this study indicate that changing the concentration of the dietary limiting amino acid in the prepyriform cortex influenced dietary selection and food intake separately.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1287-1292 |
| Number of pages | 6 |
| Journal | Journal of Nutrition |
| Volume | 121 |
| Issue number | 8 |
| DOIs | |
| State | Published - Jan 1 1991 |
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Keywords
- Amino acid imbalance
- Dietary selection
- Food intake
- Prepyriform cortex
- Rats
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Threonine concentration in the prepyriform cortex has separate effects on dietary selection and intake of a threonine-imbalanced diet by rats. / Beverly, J. L.; Gietzen, D. W.; Rogers, Quinton.
In: Journal of Nutrition, Vol. 121, No. 8, 01.01.1991, p. 1287-1292.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Threonine concentration in the prepyriform cortex has separate effects on dietary selection and intake of a threonine-imbalanced diet by rats
AU - Beverly, J. L.
AU - Gietzen, D. W.
AU - Rogers, Quinton
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Dietary selection and intake of a threonine-imbalanced diet were evaluated after increasing the concentration of the dietary limiting amino acid in the prepyriform cortex. Selection against the threonine-imbalanced diet in favor of a protein-free diet was reversed when 2 or 4 nmol threonine was injected bilaterally into the prepyriform cortex. However, intake of the threonine-imbalanced diet was significantly increased only after injection of 2 nmol threonine. The reduced intake of the threonine-imbalanced diet, compared to the basal diet, after injection of 4 nmol threonine was not the result of an excess in the concentration of amino acid (or nitrogen) injected into the PPC because intake of the threonine-basal diet was not reduced when 4 nmol threonine was administered. Intake of the threonine-imbalanced diet was also increased after injection of 2 nmol threonine plus 2 nmol isoleucine but not after injections of 2 nmol isoleucine. The changes in food intake when an imbalanced diet is fed appear to be the result of at least two separable responses: recognition of a diet as having an amino acid imbalance, as indicated by dietary choice, and reduction in food intake. The results of this study indicate that changing the concentration of the dietary limiting amino acid in the prepyriform cortex influenced dietary selection and food intake separately.
AB - Dietary selection and intake of a threonine-imbalanced diet were evaluated after increasing the concentration of the dietary limiting amino acid in the prepyriform cortex. Selection against the threonine-imbalanced diet in favor of a protein-free diet was reversed when 2 or 4 nmol threonine was injected bilaterally into the prepyriform cortex. However, intake of the threonine-imbalanced diet was significantly increased only after injection of 2 nmol threonine. The reduced intake of the threonine-imbalanced diet, compared to the basal diet, after injection of 4 nmol threonine was not the result of an excess in the concentration of amino acid (or nitrogen) injected into the PPC because intake of the threonine-basal diet was not reduced when 4 nmol threonine was administered. Intake of the threonine-imbalanced diet was also increased after injection of 2 nmol threonine plus 2 nmol isoleucine but not after injections of 2 nmol isoleucine. The changes in food intake when an imbalanced diet is fed appear to be the result of at least two separable responses: recognition of a diet as having an amino acid imbalance, as indicated by dietary choice, and reduction in food intake. The results of this study indicate that changing the concentration of the dietary limiting amino acid in the prepyriform cortex influenced dietary selection and food intake separately.
KW - Amino acid imbalance
KW - Dietary selection
KW - Food intake
KW - Prepyriform cortex
KW - Rats
UR - http://www.scopus.com/inward/record.url?scp=0026331513&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026331513&partnerID=8YFLogxK
U2 - 10.1093/jn/121.8.1287
DO - 10.1093/jn/121.8.1287
M3 - Article
C2 - 1907316
AN - SCOPUS:0026331513
VL - 121
SP - 1287
EP - 1292
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 8
ER -