Abstract
Recent efforts to understand breast cancer biology involve three interrelated themes that are founded on a combination of clinical and experimental observations. The central concept is gene addiction. The clinical dilemma is the escape from gene addiction, which is mediated, in part, by phenotypic plasticity as exemplified by epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition. Finally, cancer stem cells are now recognized as the basis for minimal residual disease and malignant progression over time. These themes cooperate in breast cancer, as induction of epithelial-to-mesenchymal transition enhances self-renewal and expression of cancer stem cells, which are believed to facilitate tumor resistance.
| Original language | English (US) |
|---|---|
| Article number | 216 |
| Journal | Breast Cancer Research |
| Volume | 13 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 25 2011 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
- Medicine(all)
Cite this
Three interrelated themes in current breast cancer research : Gene addiction, phenotypic plasticity, and cancer stem cells. / Cardiff, Robert; Couto, Suzana; Bolon, Brad.
In: Breast Cancer Research, Vol. 13, No. 5, 216, 25.10.2011.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Three interrelated themes in current breast cancer research
T2 - Gene addiction, phenotypic plasticity, and cancer stem cells
AU - Cardiff, Robert
AU - Couto, Suzana
AU - Bolon, Brad
PY - 2011/10/25
Y1 - 2011/10/25
N2 - Recent efforts to understand breast cancer biology involve three interrelated themes that are founded on a combination of clinical and experimental observations. The central concept is gene addiction. The clinical dilemma is the escape from gene addiction, which is mediated, in part, by phenotypic plasticity as exemplified by epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition. Finally, cancer stem cells are now recognized as the basis for minimal residual disease and malignant progression over time. These themes cooperate in breast cancer, as induction of epithelial-to-mesenchymal transition enhances self-renewal and expression of cancer stem cells, which are believed to facilitate tumor resistance.
AB - Recent efforts to understand breast cancer biology involve three interrelated themes that are founded on a combination of clinical and experimental observations. The central concept is gene addiction. The clinical dilemma is the escape from gene addiction, which is mediated, in part, by phenotypic plasticity as exemplified by epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition. Finally, cancer stem cells are now recognized as the basis for minimal residual disease and malignant progression over time. These themes cooperate in breast cancer, as induction of epithelial-to-mesenchymal transition enhances self-renewal and expression of cancer stem cells, which are believed to facilitate tumor resistance.
UR - http://www.scopus.com/inward/record.url?scp=81255175666&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=81255175666&partnerID=8YFLogxK
U2 - 10.1186/bcr2887
DO - 10.1186/bcr2887
M3 - Review article
C2 - 22067349
AN - SCOPUS:81255175666
VL - 13
JO - Breast Cancer Research
JF - Breast Cancer Research
SN - 1465-5411
IS - 5
M1 - 216
ER -