Abstract
We propose a new classification for immune myasthenia based on antibody pattern. The types of immune myasthenia presently characterized by known antibody targets segregate into three groups: type 1, in which the muscle target is the acetylcholine receptor only; type 2, in which titin antibodies are present in addition to acetylcholine receptor antibodies; and type 3, in which muscle-specific kinase antibodies are present in the absence of acetyl-choline receptor antibodies. The immune target is unknown in the patients with immune myasthenia not associated with these antibodies. This classification has advantages over the present classifications as regards homogeneity of groups, etiology, mechanism of disease, and prognosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 453-456 |
| Number of pages | 4 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 998 |
| DOIs | |
| State | Published - 2003 |
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Keywords
- Acetylcholine receptor (AChR)
- Antibody (Ab)
- Immune myasthenia (IM)
- Pathogenicity
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Three forms of immune myasthenia. / Agius, Mark A.; Richman, David P; Fairclough, Robert H; Aarli, Johan; Gilhus, Nils Erik; Romi, Fredrik.
In: Annals of the New York Academy of Sciences, Vol. 998, 2003, p. 453-456.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Three forms of immune myasthenia
AU - Agius, Mark A.
AU - Richman, David P
AU - Fairclough, Robert H
AU - Aarli, Johan
AU - Gilhus, Nils Erik
AU - Romi, Fredrik
PY - 2003
Y1 - 2003
N2 - We propose a new classification for immune myasthenia based on antibody pattern. The types of immune myasthenia presently characterized by known antibody targets segregate into three groups: type 1, in which the muscle target is the acetylcholine receptor only; type 2, in which titin antibodies are present in addition to acetylcholine receptor antibodies; and type 3, in which muscle-specific kinase antibodies are present in the absence of acetyl-choline receptor antibodies. The immune target is unknown in the patients with immune myasthenia not associated with these antibodies. This classification has advantages over the present classifications as regards homogeneity of groups, etiology, mechanism of disease, and prognosis.
AB - We propose a new classification for immune myasthenia based on antibody pattern. The types of immune myasthenia presently characterized by known antibody targets segregate into three groups: type 1, in which the muscle target is the acetylcholine receptor only; type 2, in which titin antibodies are present in addition to acetylcholine receptor antibodies; and type 3, in which muscle-specific kinase antibodies are present in the absence of acetyl-choline receptor antibodies. The immune target is unknown in the patients with immune myasthenia not associated with these antibodies. This classification has advantages over the present classifications as regards homogeneity of groups, etiology, mechanism of disease, and prognosis.
KW - Acetylcholine receptor (AChR)
KW - Antibody (Ab)
KW - Immune myasthenia (IM)
KW - Pathogenicity
UR - http://www.scopus.com/inward/record.url?scp=0141727660&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141727660&partnerID=8YFLogxK
U2 - 10.1196/annals.1254.059
DO - 10.1196/annals.1254.059
M3 - Article
VL - 998
SP - 453
EP - 456
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -