Three forms of immune myasthenia

Mark A. Agius, David P Richman, Robert H Fairclough, Johan Aarli, Nils Erik Gilhus, Fredrik Romi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We propose a new classification for immune myasthenia based on antibody pattern. The types of immune myasthenia presently characterized by known antibody targets segregate into three groups: type 1, in which the muscle target is the acetylcholine receptor only; type 2, in which titin antibodies are present in addition to acetylcholine receptor antibodies; and type 3, in which muscle-specific kinase antibodies are present in the absence of acetyl-choline receptor antibodies. The immune target is unknown in the patients with immune myasthenia not associated with these antibodies. This classification has advantages over the present classifications as regards homogeneity of groups, etiology, mechanism of disease, and prognosis.

Original languageEnglish (US)
Pages (from-to)453-456
Number of pages4
JournalAnnals of the New York Academy of Sciences
Volume998
DOIs
StatePublished - 2003

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Antibodies
Cholinergic Receptors
Muscle
Connectin
Muscles
Choline
Phosphotransferases
Etiology
Homogeneity

Keywords

  • Acetylcholine receptor (AChR)
  • Antibody (Ab)
  • Immune myasthenia (IM)
  • Pathogenicity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Three forms of immune myasthenia. / Agius, Mark A.; Richman, David P; Fairclough, Robert H; Aarli, Johan; Gilhus, Nils Erik; Romi, Fredrik.

In: Annals of the New York Academy of Sciences, Vol. 998, 2003, p. 453-456.

Research output: Contribution to journalArticle

Agius, Mark A. ; Richman, David P ; Fairclough, Robert H ; Aarli, Johan ; Gilhus, Nils Erik ; Romi, Fredrik. / Three forms of immune myasthenia. In: Annals of the New York Academy of Sciences. 2003 ; Vol. 998. pp. 453-456.
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