Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration

Yueli Chen, Laurel N. Vuong, Jonathan Liu, Joseph Ho, Vivek Srinivasan, Iwona Gorczynska, Andre J. Witkin, Jay S. Duker, Joel Schuman, James G. Fujimoto

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Ultrahigh resolution optical coherence tomography (OCT) enhances the ability to visualize different intra retinal layers. In age-related macular degeneration (AMD), pathological changes in individual retinal layers, including photoreceptor inner and outer segments and retinal pigment epithelium, can be detected. OCT using spectral / Fourier domain detection enables high speed, volumetric imaging of the macula, which provides comprehensive three-dimensional tomographic and morphologic information. We present a case series of AMD patients, from mild drusen to more advanced geographic atrophy and exudative AMD. Patients were imaged with a research prototype, ultrahigh resolution spectral / Fourier domain OCT instrument with 3.5 μm axial image resolution operating at 25,000 axial scans per second. These cases provide representative volumetric dataseis of well-documented AMD pathologies which could be used for the development of visualization and imaging processing methods and algorithms.

Original languageEnglish (US)
Pages (from-to)4046-4060
Number of pages15
JournalOptics Express
Volume17
Issue number5
DOIs
StatePublished - Mar 2 2009
Externally publishedYes

Fingerprint

degeneration
tomography
atrophy
photoreceptors
epithelium
image resolution
pathology
pigments
spectral resolution
prototypes
high speed

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration. / Chen, Yueli; Vuong, Laurel N.; Liu, Jonathan; Ho, Joseph; Srinivasan, Vivek; Gorczynska, Iwona; Witkin, Andre J.; Duker, Jay S.; Schuman, Joel; Fujimoto, James G.

In: Optics Express, Vol. 17, No. 5, 02.03.2009, p. 4046-4060.

Research output: Contribution to journalArticle

Chen, Y, Vuong, LN, Liu, J, Ho, J, Srinivasan, V, Gorczynska, I, Witkin, AJ, Duker, JS, Schuman, J & Fujimoto, JG 2009, 'Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration', Optics Express, vol. 17, no. 5, pp. 4046-4060. https://doi.org/10.1364/OE.17.004046
Chen, Yueli ; Vuong, Laurel N. ; Liu, Jonathan ; Ho, Joseph ; Srinivasan, Vivek ; Gorczynska, Iwona ; Witkin, Andre J. ; Duker, Jay S. ; Schuman, Joel ; Fujimoto, James G. / Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration. In: Optics Express. 2009 ; Vol. 17, No. 5. pp. 4046-4060.
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