Three-dimensional reconstruction of icosahedral particles - The uncommon line

S. D. Fuller, S. J. Butcher, R. H. Cheng, T. S. Baker

Research output: Contribution to journalArticlepeer-review

189 Scopus citations


The past few years have seen an explosion in the number of viral structures determined by icosahedral reconstruction from cryoelectron micrographs. The success of this work has depended upon a combination of the high-fidelity but low-contrast information contained in these images with efficient algorithms for determining particle orientation and three-dimensional structure. This review describes the principles behind the most commonly used method of reconstruction of the icosahedral particles and the method's implementation in an icosahedral reconstruction program suite.

Original languageEnglish (US)
Pages (from-to)48-55
Number of pages8
JournalJournal of Structural Biology
Issue number1
StatePublished - Jan 1996
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology


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