Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart

Fujian Qu, Crystal M Ripplinger, Vladimir P. Nikolski, Cindy Grimm, Igor R. Efimov

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Cardiac fluorescent optical imaging provides the unique opportunity to investigate the dynamics of propagating electrical waves during ventricular arrhythmias and the termination of arrhythmias by strong electric shocks. Panoramic imaging systems using charge-coupled device (CCD) cameras as the photodetector have been developed to overcome the inability to monitor electrical activity from the entire cardiac surface. Photodiode arrays (PDAs) are known to have higher temporal resolution and signal quality, but lower spatial resolution compared to CCD cameras. We construct a panoramic imaging system with three PDAs and image Langendorff perfused rabbit hearts (n=18) during normal sinus rhythm, epicardial pacing, and arrhythmias. The recorded spatiotemporal dynamics of electrical activity is texture mapped onto a reconstructed 3-D geometrical heart model specific to each heart studied. The PDA-based system provides sufficient spatial resolution (1.72 mm without interpolation ) for the study of wavefront propagation in the rabbit heart. The reconstructed 3-D electrical activity provides us with a powerful tool to investigate the fundamental mechanisms of arrhythmia maintenance and termination.

Original languageEnglish (US)
Article number044019
JournalJournal of Biomedical Optics
Volume12
Issue number4
DOIs
StatePublished - Jul 2007
Externally publishedYes

Fingerprint

arrhythmia
Three-Dimensional Imaging
rabbits
Cardiac Arrhythmias
Photodiodes
Rabbits
photodiodes
Imaging techniques
CCD cameras
Imaging systems
charge coupled devices
spatial resolution
cameras
sinuses
rhythm
Equipment and Supplies
Optical Imaging
Wavefronts
Photodetectors
temporal resolution

Keywords

  • Arrhythmia
  • Defibrillation
  • Electrophysiology
  • Optical mapping
  • Panoramic imaging

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Clinical Biochemistry

Cite this

Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart. / Qu, Fujian; Ripplinger, Crystal M; Nikolski, Vladimir P.; Grimm, Cindy; Efimov, Igor R.

In: Journal of Biomedical Optics, Vol. 12, No. 4, 044019, 07.2007.

Research output: Contribution to journalArticle

Qu, Fujian ; Ripplinger, Crystal M ; Nikolski, Vladimir P. ; Grimm, Cindy ; Efimov, Igor R. / Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart. In: Journal of Biomedical Optics. 2007 ; Vol. 12, No. 4.
@article{04ebd18a01e949fcadedb24cde04c7fa,
title = "Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart",
abstract = "Cardiac fluorescent optical imaging provides the unique opportunity to investigate the dynamics of propagating electrical waves during ventricular arrhythmias and the termination of arrhythmias by strong electric shocks. Panoramic imaging systems using charge-coupled device (CCD) cameras as the photodetector have been developed to overcome the inability to monitor electrical activity from the entire cardiac surface. Photodiode arrays (PDAs) are known to have higher temporal resolution and signal quality, but lower spatial resolution compared to CCD cameras. We construct a panoramic imaging system with three PDAs and image Langendorff perfused rabbit hearts (n=18) during normal sinus rhythm, epicardial pacing, and arrhythmias. The recorded spatiotemporal dynamics of electrical activity is texture mapped onto a reconstructed 3-D geometrical heart model specific to each heart studied. The PDA-based system provides sufficient spatial resolution (1.72 mm without interpolation ) for the study of wavefront propagation in the rabbit heart. The reconstructed 3-D electrical activity provides us with a powerful tool to investigate the fundamental mechanisms of arrhythmia maintenance and termination.",
keywords = "Arrhythmia, Defibrillation, Electrophysiology, Optical mapping, Panoramic imaging",
author = "Fujian Qu and Ripplinger, {Crystal M} and Nikolski, {Vladimir P.} and Cindy Grimm and Efimov, {Igor R.}",
year = "2007",
month = "7",
doi = "10.1117/1.2753748",
language = "English (US)",
volume = "12",
journal = "Journal of Biomedical Optics",
issn = "1083-3668",
publisher = "SPIE",
number = "4",

}

TY - JOUR

T1 - Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart

AU - Qu, Fujian

AU - Ripplinger, Crystal M

AU - Nikolski, Vladimir P.

AU - Grimm, Cindy

AU - Efimov, Igor R.

PY - 2007/7

Y1 - 2007/7

N2 - Cardiac fluorescent optical imaging provides the unique opportunity to investigate the dynamics of propagating electrical waves during ventricular arrhythmias and the termination of arrhythmias by strong electric shocks. Panoramic imaging systems using charge-coupled device (CCD) cameras as the photodetector have been developed to overcome the inability to monitor electrical activity from the entire cardiac surface. Photodiode arrays (PDAs) are known to have higher temporal resolution and signal quality, but lower spatial resolution compared to CCD cameras. We construct a panoramic imaging system with three PDAs and image Langendorff perfused rabbit hearts (n=18) during normal sinus rhythm, epicardial pacing, and arrhythmias. The recorded spatiotemporal dynamics of electrical activity is texture mapped onto a reconstructed 3-D geometrical heart model specific to each heart studied. The PDA-based system provides sufficient spatial resolution (1.72 mm without interpolation ) for the study of wavefront propagation in the rabbit heart. The reconstructed 3-D electrical activity provides us with a powerful tool to investigate the fundamental mechanisms of arrhythmia maintenance and termination.

AB - Cardiac fluorescent optical imaging provides the unique opportunity to investigate the dynamics of propagating electrical waves during ventricular arrhythmias and the termination of arrhythmias by strong electric shocks. Panoramic imaging systems using charge-coupled device (CCD) cameras as the photodetector have been developed to overcome the inability to monitor electrical activity from the entire cardiac surface. Photodiode arrays (PDAs) are known to have higher temporal resolution and signal quality, but lower spatial resolution compared to CCD cameras. We construct a panoramic imaging system with three PDAs and image Langendorff perfused rabbit hearts (n=18) during normal sinus rhythm, epicardial pacing, and arrhythmias. The recorded spatiotemporal dynamics of electrical activity is texture mapped onto a reconstructed 3-D geometrical heart model specific to each heart studied. The PDA-based system provides sufficient spatial resolution (1.72 mm without interpolation ) for the study of wavefront propagation in the rabbit heart. The reconstructed 3-D electrical activity provides us with a powerful tool to investigate the fundamental mechanisms of arrhythmia maintenance and termination.

KW - Arrhythmia

KW - Defibrillation

KW - Electrophysiology

KW - Optical mapping

KW - Panoramic imaging

UR - http://www.scopus.com/inward/record.url?scp=35949001692&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35949001692&partnerID=8YFLogxK

U2 - 10.1117/1.2753748

DO - 10.1117/1.2753748

M3 - Article

C2 - 17867823

AN - SCOPUS:35949001692

VL - 12

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

SN - 1083-3668

IS - 4

M1 - 044019

ER -