Three-dimensional in vivo morphometry of trabecular bone in the OVX rat model of osteoporosis

J. H. Kinney, J. T. Ryaby, D. L. Haupt, Nancy E Lane

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

This paper describes the application of synchrotron radiation microtomography to osteoporosis research. By taking advantage of the high intensity, collimation, and monochromaticity of synchrotron radiation, we have been able to image the three-dimensional trabecular bone structure in living rats, thus providing serial data on the earliest architectural changes that occur with estrogen loss. Results from these in vivo animal experiments demonstrate that one of the earliest manifestations of estrogen loss, in addition to a decrease in the amount of trabecular bone, is decreased connectivity. We demonstrate that estrogen replacement therapy, when initiated soon after significant changes have occurred, restores bone mass to baseline levels but does not recover the trabecular connectivity. Even without an associated recovery in trabecular connectivity, finite element calculations on the three-dimensional images suggest that estrogen recovers the original structural modulus of elasticity. We believe the recovery of the elastic properties is due to an increase in trabecular thickness above baseline values.

Original languageEnglish (US)
Pages (from-to)339-350
Number of pages12
JournalTechnology and Health Care
Volume6
Issue number5-6
StatePublished - 1998
Externally publishedYes

Fingerprint

Osteoporosis
Rats
Bone
Estrogens
Synchrotrons
Three-Dimensional Imaging
Synchrotron radiation
Radiation
Estrogen Replacement Therapy
Elastic Modulus
Recovery
Bone and Bones
Animals
Elastic moduli
Research
Cancellous Bone
Experiments

Keywords

  • Estrogen
  • Microtomography
  • Osteoporosis
  • Rat model
  • Trabecular bone

ASJC Scopus subject areas

  • Biophysics

Cite this

Three-dimensional in vivo morphometry of trabecular bone in the OVX rat model of osteoporosis. / Kinney, J. H.; Ryaby, J. T.; Haupt, D. L.; Lane, Nancy E.

In: Technology and Health Care, Vol. 6, No. 5-6, 1998, p. 339-350.

Research output: Contribution to journalArticle

Kinney, J. H. ; Ryaby, J. T. ; Haupt, D. L. ; Lane, Nancy E. / Three-dimensional in vivo morphometry of trabecular bone in the OVX rat model of osteoporosis. In: Technology and Health Care. 1998 ; Vol. 6, No. 5-6. pp. 339-350.
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