Three-dimensional fluorescence optical tomography in small-animal imaging using simultaneous positron-emission-tomography priors

Changqing Li, Guobao Wang, Jinyi Qi, Simon R Cherry

Research output: Contribution to journalArticle

37 Scopus citations


We propose three-dimensional fluorescence optical tomography imaging for small animals guided by simultaneous priors from positron emission tomography (PET). Using a sparsity regularization, the target prior from PET images was incorporated into the reconstruction algorithm for optical imaging. The method and algorithms are validated with numerical simulations and a phantom experiment performed on a combined optical-PET scanner based on a conical mirror geometry.

Original languageEnglish (US)
Pages (from-to)2933-2935
Number of pages3
JournalOptics Letters
Issue number19
StatePublished - Oct 1 2009


ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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