Thoracic computed tomography of patients infected with the human immunodeficiency virus: Relevance for the course of disease

Friedrich D Knollmann, Thomas Grünewald, Julia Neitzert, Frank Bergmann, Hannes Schedel, Hans D. Pohle, Roland Felix

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

To determine the diagnostic accuracy and prognostic implications of thoracic computed tomography (CT) in patients with human immunodeficiency virus infection (HIV), CT scans of 154 HIV-infected patients (mean age, 41 years; range 23-65 years; 18 female) with suspicion of pulmonary disease were retrospectively reviewed for signs of disease by two investigators blinded to clinical data other than positive HIV serology. Abnormal CT features were correlated with CD4-T lymphocyte count, histologic or microbiologic diagnosis, and survival. Computed tomography detected features of pulmonary disease in 133 patients. A recent chest film was available in 96 patients, and it was normal in 16. In 17 of 99 patients (17%) with histologic or microbiologic correlation, pathologic CT features could be demonstrated, though histologic and microbiological studies were unrevealing. Median survival was 649 days. Confluent pulmonary infiltrates and bilateral masses on CT indicated advanced disease with a median survival of 115 days (n = 11, p = 0.0005) and 174 days (n = 15, p < 0.0001), respectively. The authors concluded that thoracic CT detects pulmonary lesions in an appreciable portion of HIV-infected patients in whom chest radiographs, microbiologic methods, or histology failed to establish a diagnosis, and that CT findings allow for an estimation of patient survival in acquired immunodeficiency syndrome.

Original languageEnglish (US)
Pages (from-to)185-193
Number of pages9
JournalJournal of Thoracic Imaging
Volume14
Issue number3
StatePublished - Jul 1999
Externally publishedYes

Keywords

  • Acquired immunodeficiency syndrome
  • Computed tomography
  • Human immunodeficiency virus
  • Thorax

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pulmonary and Respiratory Medicine
  • Radiological and Ultrasound Technology

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    Knollmann, F. D., Grünewald, T., Neitzert, J., Bergmann, F., Schedel, H., Pohle, H. D., & Felix, R. (1999). Thoracic computed tomography of patients infected with the human immunodeficiency virus: Relevance for the course of disease. Journal of Thoracic Imaging, 14(3), 185-193.