Thinking outside the synapse: Glycine at extrasynaptic NMDA receptors

John Gray, Roger A. Nicoll

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


In this issue, Papouin et al. show that glycine is the endogenous coagonist for extrasynaptic NMDA receptors (NMDARs), unlike at synapses where the coagonist is d-serine. By enzymatically degrading endogenous glycine, they begin to address the enigmatic physiological and pathological roles for extrasynaptic NMDARs.

Original languageEnglish (US)
Pages (from-to)455-456
Number of pages2
Issue number3
StatePublished - Aug 3 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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