Thin-film coupled fluid-solid analysis of flow through the Ahmed™ glaucoma drainage device

Matthew S. Stay, Tingrui Pan, J. David Brown, Babak Ziaie, Victor H. Barocas

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The Ahmed™ glaucoma valve (AGV) is a popular glaucoma drainage device, allowing maintenance of normal intraocular pressure in patients with reduced trabecular outflow facility. The uniquely attractive feature of the AGV, in contrast to other available drainage devices, is its variable resistance in response to changes in flow rate. As a result of this variable resistance, the AGV maintains a pressure drop between 7 and 12 mm Hg for a wide range of aqueous humor flow rates. In this paper, we demonstrate that the nonlinear behavior of the AGV is a direct result of the flexibility of the valve material. Due to the thin geometry of the system, the leaflets of the AGV were modeled using the von Kármán plate theory coupled to a Reynolds lubrication theory model of the aqueous humor flow through the valve. The resulting two-dimensional coupled steady-state partial differential equation system was solved by the finite element method. The Poisson's ratio of the valve was set to 0.45, and the modulus was regressed to experimental data, giving a best-fit value 4.2 MPa. Simulation results compared favorably with previous experimental studies and our own pressure-drop/flow-rate data. For an in vitro flow of 1.6 μL/min, we calculated a pressure drop of 5.8 mm Hg and measured a pressure drop of 5.2 ± 0.4 mm Hg. As flow rate was increased, pressure drop rose in a strongly sublinear fashion, with a flow rate of 20 μL/min giving a predicted pressure drop of only 10.9 mm Hg and a measured pressure drop of 10.5 ± 1.1 mm Hg. The AGV model was then applied to simulate in vivo conditions. For an aqueous humor flow rate of 1.5-3.0 μL/min, the calculated pressure drops were 5.3 and 6.3 mm Hg.

Original languageEnglish (US)
Pages (from-to)776-781
Number of pages6
JournalJournal of Biomechanical Engineering
Volume127
Issue number5
DOIs
StatePublished - Oct 1 2005
Externally publishedYes

Fingerprint

Glaucoma
Drainage
Pressure drop
Pressure
Thin films
Equipment and Supplies
Fluids
Flow rate
Aqueous Humor
Lubrication
Poisson ratio
Intraocular Pressure
Partial differential equations
Maintenance
Finite element method
Geometry

Keywords

  • Finite Element Method
  • Intraocular Pressure
  • Lubrication Theory
  • Von Kármán Plate Theory

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

Cite this

Thin-film coupled fluid-solid analysis of flow through the Ahmed™ glaucoma drainage device. / Stay, Matthew S.; Pan, Tingrui; Brown, J. David; Ziaie, Babak; Barocas, Victor H.

In: Journal of Biomechanical Engineering, Vol. 127, No. 5, 01.10.2005, p. 776-781.

Research output: Contribution to journalArticle

Stay, Matthew S. ; Pan, Tingrui ; Brown, J. David ; Ziaie, Babak ; Barocas, Victor H. / Thin-film coupled fluid-solid analysis of flow through the Ahmed™ glaucoma drainage device. In: Journal of Biomechanical Engineering. 2005 ; Vol. 127, No. 5. pp. 776-781.
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