The effects of thiamine (B1) deficiency on local CMR(glu) (LMCR(glu)) in the vestibular nuclei were studied with the 14C-2-deoxyglucose autoradiographic method in awake asymptomatic and symptomatic rats. Animals on the B1-deficient diet for 98 days developed symptoms of ataxia and opisthotonos. The results show that B1 deficiency produces: bilateral vestibular nuclei lesions in symptomatic animals; very low LCMR(glu) rates in these lesions; and limitation of glial proliferation in the lesions. Giving B1 to B1-deficient symptomatic animals produced a cellular proliferative response consisting mostly of microglia in the lesioned areas of the vestibular nuclei and a high LCMR(glu) rate in the regions of microglial proliferation.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Cerebral Blood Flow and Metabolism|
|State||Published - 1982|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism