Thermo-mechanical mechanism of laser-assisted alteration and stabilization of micro pore structure in eye-sclera

Olga Baum; Sebastian Wachsmann-Hogiu; Emil Sobol

doi:10.1117/12.2289885

Thermo-mechanical mechanism of laser-assisted alteration and stabilization of micro pore structure in eye-sclera

Olga Baum, Sebastian Wachsmann-Hogiu, Emil Sobol

Pathology and Laboratory Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Thermo-mechanical effect of laser radiation is a basis of new method of normalization of intraocular pressure in glaucomatous eyes due to laser-assisted pore formation in eye sclera. Laser-induced creation of pores in sclera increases hydraulic permeability. Stability of laser-induced pore system is achieved via gas nano-bubbles arisen in the sclera under laser radiation as a result of temperature dependency of gas solubility. The stabilization of laser-induced gas and pore systems in the tissue is an important mechanism for a long lasting healing of glaucoma observed in clinical trials with one year follow-up.

Original language	English (US)
Title of host publication	Optical Elastography and Tissue Biomechanics V
Publisher	SPIE
Volume	10496
ISBN (Electronic)	9781510614772
DOIs	https://doi.org/10.1117/12.2289885
State	Published - Jan 1 2018
Event	Optical Elastography and Tissue Biomechanics V 2018 - San Francisco, United States Duration: Jan 27 2018 → Jan 28 2018

Other

Other	Optical Elastography and Tissue Biomechanics V 2018
Country	United States
City	San Francisco
Period	1/27/18 → 1/28/18

Keywords

atomic force microscopy
gas nanobubbles
glaucoma
intraocular pressure
laser
Stabilization mechanism
super-resolution structured-illumination microscopy
thermo-mechanical stress

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

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10.1117/12.2289885

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Cite this

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title = "Thermo-mechanical mechanism of laser-assisted alteration and stabilization of micro pore structure in eye-sclera",

abstract = "Thermo-mechanical effect of laser radiation is a basis of new method of normalization of intraocular pressure in glaucomatous eyes due to laser-assisted pore formation in eye sclera. Laser-induced creation of pores in sclera increases hydraulic permeability. Stability of laser-induced pore system is achieved via gas nano-bubbles arisen in the sclera under laser radiation as a result of temperature dependency of gas solubility. The stabilization of laser-induced gas and pore systems in the tissue is an important mechanism for a long lasting healing of glaucoma observed in clinical trials with one year follow-up.",

keywords = "atomic force microscopy, gas nanobubbles, glaucoma, intraocular pressure, laser, Stabilization mechanism, super-resolution structured-illumination microscopy, thermo-mechanical stress",

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year = "2018",

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language = "English (US)",

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AU - Baum, Olga

AU - Wachsmann-Hogiu, Sebastian

AU - Sobol, Emil

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Y1 - 2018/1/1

N2 - Thermo-mechanical effect of laser radiation is a basis of new method of normalization of intraocular pressure in glaucomatous eyes due to laser-assisted pore formation in eye sclera. Laser-induced creation of pores in sclera increases hydraulic permeability. Stability of laser-induced pore system is achieved via gas nano-bubbles arisen in the sclera under laser radiation as a result of temperature dependency of gas solubility. The stabilization of laser-induced gas and pore systems in the tissue is an important mechanism for a long lasting healing of glaucoma observed in clinical trials with one year follow-up.

AB - Thermo-mechanical effect of laser radiation is a basis of new method of normalization of intraocular pressure in glaucomatous eyes due to laser-assisted pore formation in eye sclera. Laser-induced creation of pores in sclera increases hydraulic permeability. Stability of laser-induced pore system is achieved via gas nano-bubbles arisen in the sclera under laser radiation as a result of temperature dependency of gas solubility. The stabilization of laser-induced gas and pore systems in the tissue is an important mechanism for a long lasting healing of glaucoma observed in clinical trials with one year follow-up.

KW - atomic force microscopy

KW - gas nanobubbles

KW - glaucoma

KW - intraocular pressure

KW - laser

KW - Stabilization mechanism

KW - super-resolution structured-illumination microscopy

KW - thermo-mechanical stress

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