The relative cleavage of an alcohol from a panel of amino esters and amino carbonates via intramolecular cyclization was examined as a mechanism for substrate release. Thermal stability at 37 °C was observed only for the seven-membered ring progenitors. Applicability of the approach was illustrated by δ-lactam formation within a poly(dimethylsiloxane) microchannel for release of a captured fluorescent probe.
- Drug delivery
- Poly(dimethylsiloxane) microchannel
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery