Abstract
Two Nb rat prostatic adenocarcinomas, 13 Pr-12, an autonomous tumor, and 2 Pr-128, an androgen-dependent tumor, were transplanted into groups of congenitally athymic nude mice. The agents used for treatment of these tumors are agents characteristically not used in treatment of prostatic adenocarcinoma in humans. However, these have been efficacious in treating other solid malignancies. Both agents, BCNU and Actinomycin-D, were efficacious in producing tumor regression and in causing at least a temporary decrease in tumor growth. The combination of the Nb rat prostatic adenocarcinoma model and nude mouse is presented as an appropriate system to screen therapeutic agents that have proved efficacious in treatment of other solid malignancies but have not been used in treating prostatic adenocarcinoma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 265-272 |
| Number of pages | 8 |
| Journal | Journal of Surgical Oncology |
| Volume | 16 |
| Issue number | 3 |
| State | Published - 1981 |
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ASJC Scopus subject areas
- Oncology
- Surgery
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Therapy for Nb rat tumor transplanted in athymic mice. / Drago, J. R.; Goldman, L. B.; Worgul, T.; Gershwin, M. Eric.
In: Journal of Surgical Oncology, Vol. 16, No. 3, 1981, p. 265-272.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Therapy for Nb rat tumor transplanted in athymic mice
AU - Drago, J. R.
AU - Goldman, L. B.
AU - Worgul, T.
AU - Gershwin, M. Eric
PY - 1981
Y1 - 1981
N2 - Two Nb rat prostatic adenocarcinomas, 13 Pr-12, an autonomous tumor, and 2 Pr-128, an androgen-dependent tumor, were transplanted into groups of congenitally athymic nude mice. The agents used for treatment of these tumors are agents characteristically not used in treatment of prostatic adenocarcinoma in humans. However, these have been efficacious in treating other solid malignancies. Both agents, BCNU and Actinomycin-D, were efficacious in producing tumor regression and in causing at least a temporary decrease in tumor growth. The combination of the Nb rat prostatic adenocarcinoma model and nude mouse is presented as an appropriate system to screen therapeutic agents that have proved efficacious in treatment of other solid malignancies but have not been used in treating prostatic adenocarcinoma.
AB - Two Nb rat prostatic adenocarcinomas, 13 Pr-12, an autonomous tumor, and 2 Pr-128, an androgen-dependent tumor, were transplanted into groups of congenitally athymic nude mice. The agents used for treatment of these tumors are agents characteristically not used in treatment of prostatic adenocarcinoma in humans. However, these have been efficacious in treating other solid malignancies. Both agents, BCNU and Actinomycin-D, were efficacious in producing tumor regression and in causing at least a temporary decrease in tumor growth. The combination of the Nb rat prostatic adenocarcinoma model and nude mouse is presented as an appropriate system to screen therapeutic agents that have proved efficacious in treatment of other solid malignancies but have not been used in treating prostatic adenocarcinoma.
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M3 - Article
C2 - 7218811
AN - SCOPUS:0019520120
VL - 16
SP - 265
EP - 272
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 3
ER -