Therapeutic plasma exchange for neuromyelitis optica spectrum disorder: A multicenter retrospective study by the ASFA neurologic diseases subcommittee

Tina S. Ipe, Jay S. Raval, Leonor P. Fernando, Amit Gokhale, Cyril Jacquot, Andrew D. Johnson, Haewon C. Kim, Grace F. Monis, Yunchun D. Mo, Shanna M. Morgan, Monica B. Pagano, Huy P. Pham, Kimberly Sanford, Amy E. Schmidt, Joseph Schwartz, Amy Waldman, Jennifer Webb, Jeffrey L. Winters, Yanyun Wu, Chisa YamadaEdward C.C. Wong

Research output: Contribution to journalArticle

Abstract

Importance: Neuromyelitis optica/neuromyelitis optica spectrum disorder patients' response to therapeutic plasma exchange (TPE) is currently incompletely characterized. Objective: Our study aims to understand the clinical status improvement of neuromyelitis optica/neuromyelitis optica spectrum disorder patients treated with TPE. Design, Setting, and Participants: This is a multicenter retrospective study conducted between 1 January 2003 and 31 July 2017 at 13 US hospitals performing apheresis procedures. Subjects studied were diagnosed with neuromyelitis optica/neuromyelitis optica spectrum disorder who received TPE during presentation with acute disease. Main Outcomes and Measures: The primary outcome was clinical status improvement in patients treated with TPE. Secondary measures were procedural and patient characteristics associated with response to treatment. Results: We evaluated 114 patients from 13 institutions. There was a female predilection. The largest ethnic group affected was non-Hispanic Caucasian. The average age of diagnosis was 43.1 years. The average time to diagnosis was 3.1 years. On average, five procedures were performed during each treatment series. The most commonly performed plasma volume exchange was 1.0 to 1.25 using 5% albumin as replacement fluid. Most patients (52%) did not require an additional course of TPE and noted “mild” to “moderate” clinical status improvement. Maximal symptom improvement appeared by the fourth or fifth TPE treatment. Conclusion and Relevance: TPE improved the clinical status of patients. Adults responded more favorably than children. Procedural characteristics, including number of TPEs, plasma volume exchanged, and replacement fluid used, were similar between institutions. TPE was well-tolerated and had a low severe adverse event profile.

Original languageEnglish (US)
JournalJournal of Clinical Apheresis
DOIs
StateAccepted/In press - Jan 1 2019

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Neuromyelitis Optica
Plasma Exchange
Nervous System Diseases
Multicenter Studies
Retrospective Studies
Therapeutics
Plasma Volume
Blood Component Removal
Acute Disease
Ethnic Groups
Albumins

Keywords

  • clinical status improvement
  • demographics
  • procedural
  • registry

ASJC Scopus subject areas

  • Hematology

Cite this

Therapeutic plasma exchange for neuromyelitis optica spectrum disorder : A multicenter retrospective study by the ASFA neurologic diseases subcommittee. / Ipe, Tina S.; Raval, Jay S.; Fernando, Leonor P.; Gokhale, Amit; Jacquot, Cyril; Johnson, Andrew D.; Kim, Haewon C.; Monis, Grace F.; Mo, Yunchun D.; Morgan, Shanna M.; Pagano, Monica B.; Pham, Huy P.; Sanford, Kimberly; Schmidt, Amy E.; Schwartz, Joseph; Waldman, Amy; Webb, Jennifer; Winters, Jeffrey L.; Wu, Yanyun; Yamada, Chisa; Wong, Edward C.C.

In: Journal of Clinical Apheresis, 01.01.2019.

Research output: Contribution to journalArticle

Ipe, TS, Raval, JS, Fernando, LP, Gokhale, A, Jacquot, C, Johnson, AD, Kim, HC, Monis, GF, Mo, YD, Morgan, SM, Pagano, MB, Pham, HP, Sanford, K, Schmidt, AE, Schwartz, J, Waldman, A, Webb, J, Winters, JL, Wu, Y, Yamada, C & Wong, ECC 2019, 'Therapeutic plasma exchange for neuromyelitis optica spectrum disorder: A multicenter retrospective study by the ASFA neurologic diseases subcommittee', Journal of Clinical Apheresis. https://doi.org/10.1002/jca.21754
Ipe, Tina S. ; Raval, Jay S. ; Fernando, Leonor P. ; Gokhale, Amit ; Jacquot, Cyril ; Johnson, Andrew D. ; Kim, Haewon C. ; Monis, Grace F. ; Mo, Yunchun D. ; Morgan, Shanna M. ; Pagano, Monica B. ; Pham, Huy P. ; Sanford, Kimberly ; Schmidt, Amy E. ; Schwartz, Joseph ; Waldman, Amy ; Webb, Jennifer ; Winters, Jeffrey L. ; Wu, Yanyun ; Yamada, Chisa ; Wong, Edward C.C. / Therapeutic plasma exchange for neuromyelitis optica spectrum disorder : A multicenter retrospective study by the ASFA neurologic diseases subcommittee. In: Journal of Clinical Apheresis. 2019.
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abstract = "Importance: Neuromyelitis optica/neuromyelitis optica spectrum disorder patients' response to therapeutic plasma exchange (TPE) is currently incompletely characterized. Objective: Our study aims to understand the clinical status improvement of neuromyelitis optica/neuromyelitis optica spectrum disorder patients treated with TPE. Design, Setting, and Participants: This is a multicenter retrospective study conducted between 1 January 2003 and 31 July 2017 at 13 US hospitals performing apheresis procedures. Subjects studied were diagnosed with neuromyelitis optica/neuromyelitis optica spectrum disorder who received TPE during presentation with acute disease. Main Outcomes and Measures: The primary outcome was clinical status improvement in patients treated with TPE. Secondary measures were procedural and patient characteristics associated with response to treatment. Results: We evaluated 114 patients from 13 institutions. There was a female predilection. The largest ethnic group affected was non-Hispanic Caucasian. The average age of diagnosis was 43.1 years. The average time to diagnosis was 3.1 years. On average, five procedures were performed during each treatment series. The most commonly performed plasma volume exchange was 1.0 to 1.25 using 5{\%} albumin as replacement fluid. Most patients (52{\%}) did not require an additional course of TPE and noted “mild” to “moderate” clinical status improvement. Maximal symptom improvement appeared by the fourth or fifth TPE treatment. Conclusion and Relevance: TPE improved the clinical status of patients. Adults responded more favorably than children. Procedural characteristics, including number of TPEs, plasma volume exchanged, and replacement fluid used, were similar between institutions. TPE was well-tolerated and had a low severe adverse event profile.",
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AU - Fernando, Leonor P.

AU - Gokhale, Amit

AU - Jacquot, Cyril

AU - Johnson, Andrew D.

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AU - Schwartz, Joseph

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AU - Webb, Jennifer

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AU - Yamada, Chisa

AU - Wong, Edward C.C.

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