Therapeutic manipulation of Nb rat prostatic adenocarcinomas. Chemotherapeutic evaluation of autonomous tumors

J. R. Drago, L. B. Goldman, R. E. Maurer, M. Eric Gershwin, D. D. Eckels

Research output: Contribution to journalArticle

4 Scopus citations


Nb rat autonomous prostatic adenocarcinomas were transplanted into several groups of syngeneic Nb rats. Chemotherapy using 5-fluorouracil, methotrexate, adriamycin, and cyclophosphamide was evaluated. Significance was seen with the use of these agents with varying doses. Cyclophosphamide and 5-fluorouracil treated animals had complete tumor regression whereas adriamycin and methotrexate treated animals had cessation of tumor volume increase in some groups after chemotherapy; however, neither agent causes complete tumor regression.

Original languageEnglish (US)
Pages (from-to)203-206
Number of pages4
JournalInvestigative Urology
Issue number3
StatePublished - 1979
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

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