Therapeutic manipulation of Nb rat prostatic adenocarcinomas. Chemotherapeutic evaluation of autonomous tumors

J. R. Drago; L. B. Goldman; R. E. Maurer; M. Eric Gershwin; D. D. Eckels

Therapeutic manipulation of Nb rat prostatic adenocarcinomas. Chemotherapeutic evaluation of autonomous tumors

J. R. Drago, L. B. Goldman, R. E. Maurer, M. Eric Gershwin, D. D. Eckels

Research output: Contribution to journal › Article › peer-review

Abstract

Nb rat autonomous prostatic adenocarcinomas were transplanted into several groups of syngeneic Nb rats. Chemotherapy using 5-fluorouracil, methotrexate, adriamycin, and cyclophosphamide was evaluated. Significance was seen with the use of these agents with varying doses. Cyclophosphamide and 5-fluorouracil treated animals had complete tumor regression whereas adriamycin and methotrexate treated animals had cessation of tumor volume increase in some groups after chemotherapy; however, neither agent causes complete tumor regression.

Original language	English (US)
Pages (from-to)	203-206
Number of pages	4
Journal	Investigative Urology
Volume	17
Issue number	3
State	Published - 1979
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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title = "Therapeutic manipulation of Nb rat prostatic adenocarcinomas. Chemotherapeutic evaluation of autonomous tumors",

abstract = "Nb rat autonomous prostatic adenocarcinomas were transplanted into several groups of syngeneic Nb rats. Chemotherapy using 5-fluorouracil, methotrexate, adriamycin, and cyclophosphamide was evaluated. Significance was seen with the use of these agents with varying doses. Cyclophosphamide and 5-fluorouracil treated animals had complete tumor regression whereas adriamycin and methotrexate treated animals had cessation of tumor volume increase in some groups after chemotherapy; however, neither agent causes complete tumor regression.",

author = "Drago, {J. R.} and Goldman, {L. B.} and Maurer, {R. E.} and Gershwin, {M. Eric} and Eckels, {D. D.}",

year = "1979",

language = "English (US)",

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pages = "203--206",

journal = "Journal of Urology",

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AU - Drago, J. R.

AU - Goldman, L. B.

AU - Maurer, R. E.

AU - Gershwin, M. Eric

AU - Eckels, D. D.

PY - 1979

Y1 - 1979

N2 - Nb rat autonomous prostatic adenocarcinomas were transplanted into several groups of syngeneic Nb rats. Chemotherapy using 5-fluorouracil, methotrexate, adriamycin, and cyclophosphamide was evaluated. Significance was seen with the use of these agents with varying doses. Cyclophosphamide and 5-fluorouracil treated animals had complete tumor regression whereas adriamycin and methotrexate treated animals had cessation of tumor volume increase in some groups after chemotherapy; however, neither agent causes complete tumor regression.

AB - Nb rat autonomous prostatic adenocarcinomas were transplanted into several groups of syngeneic Nb rats. Chemotherapy using 5-fluorouracil, methotrexate, adriamycin, and cyclophosphamide was evaluated. Significance was seen with the use of these agents with varying doses. Cyclophosphamide and 5-fluorouracil treated animals had complete tumor regression whereas adriamycin and methotrexate treated animals had cessation of tumor volume increase in some groups after chemotherapy; however, neither agent causes complete tumor regression.

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