Therapeutic effects of stem cells in rodent models of Huntington's disease: Review and electrophysiological findings

Sandra M. Holley, Talia Kamdjou, Jack C. Reidling, Brian Fury, Dane Coleal-Bergum, Gerhard Bauer, Leslie M. Thompson, Michael S. Levine, Carlos Cepeda

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The principal symptoms of Huntington's disease (HD), chorea, cognitive deficits, and psychiatric symptoms are associated with the massive loss of striatal and cortical projection neurons. As current drug therapies only partially alleviate symptoms, finding alternative treatments has become peremptory. Cell replacement using stem cells is a rapidly expanding field that offers such an alternative. In this review, we examine recent studies that use mesenchymal cells, as well as pluripotent, cell-derived products in animal models of HD. Additionally, we provide further electrophysiological characterization of a human neural stem cell line, ESI-017, which has already demonstrated disease-modifying properties in two mouse models of HD. Overall, the field of regenerative medicine represents a viable and promising avenue for the treatment of neurodegenerative disorders including HD.

Original languageEnglish (US)
JournalCNS Neuroscience and Therapeutics
DOIs
StateAccepted/In press - Jan 1 2018

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Keywords

  • Animal models
  • Electrophysiology
  • Huntington's disease
  • Stem cells

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Physiology (medical)
  • Pharmacology (medical)

Cite this

Holley, S. M., Kamdjou, T., Reidling, J. C., Fury, B., Coleal-Bergum, D., Bauer, G., Thompson, L. M., Levine, M. S., & Cepeda, C. (Accepted/In press). Therapeutic effects of stem cells in rodent models of Huntington's disease: Review and electrophysiological findings. CNS Neuroscience and Therapeutics. https://doi.org/10.1111/cns.12839