Therapeutic effects of paclitaxel-containing ultrasound contrast agents

Michaelann Shortencarier Tartis, Jennifer McCallan, Aaron F H Lum, Rachel LaBell, Susanne M. Stieger, Terry O. Matsunaga, Katherine W. Ferrara

Research output: Contribution to journalArticle

132 Scopus citations

Abstract

Drug delivery vehicles that combine ultrasonic and molecular targeting are shown to locally concentrate a drug in a region-of-interest. The drug delivery vehicles, referred to as acoustically active lipospheres (AALs), are microbubbles surrounded by a shell of oil and lipid. In a region limited to the focal area of ultrasound application, circulating AALs are deflected by radiation force to a vessel wall and can subsequently be fragmented. Ligands targeting the αvβ3 integrin are conjugated to the AAL shell and increase in vitro binding by 26.5-fold over nontargeted agents. Toxicity assays demonstrate that paclitaxel-containing AALs exert a greater antiproliferative effect after insonation than free paclitaxel at an equivalent concentration. Lastly, ultrasound and molecular targeting are combined to deliver a model drug to the endothelium and interstitium of chorioallantoic membrane vasculature in vivo. (E-mail: kwferrara@ucdavis.edu).

Original languageEnglish (US)
Pages (from-to)1771-1780
Number of pages10
JournalUltrasound in Medicine and Biology
Volume32
Issue number11
DOIs
StatePublished - Nov 2006

    Fingerprint

Keywords

  • αβ Acoustically active lipospheres (AALs)
  • Angiogenesis
  • Paclitaxel
  • Radiation force
  • Targeted drug delivery
  • Ultrasound contrast agents

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Tartis, M. S., McCallan, J., Lum, A. F. H., LaBell, R., Stieger, S. M., Matsunaga, T. O., & Ferrara, K. W. (2006). Therapeutic effects of paclitaxel-containing ultrasound contrast agents. Ultrasound in Medicine and Biology, 32(11), 1771-1780. https://doi.org/10.1016/j.ultrasmedbio.2006.03.017