Therapeutic effects of paclitaxel-containing ultrasound contrast agents

Michaelann Shortencarier Tartis, Jennifer McCallan, Aaron F H Lum, Rachel LaBell, Susanne M. Stieger, Terry O. Matsunaga, Katherine W. Ferrara

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Drug delivery vehicles that combine ultrasonic and molecular targeting are shown to locally concentrate a drug in a region-of-interest. The drug delivery vehicles, referred to as acoustically active lipospheres (AALs), are microbubbles surrounded by a shell of oil and lipid. In a region limited to the focal area of ultrasound application, circulating AALs are deflected by radiation force to a vessel wall and can subsequently be fragmented. Ligands targeting the αvβ3 integrin are conjugated to the AAL shell and increase in vitro binding by 26.5-fold over nontargeted agents. Toxicity assays demonstrate that paclitaxel-containing AALs exert a greater antiproliferative effect after insonation than free paclitaxel at an equivalent concentration. Lastly, ultrasound and molecular targeting are combined to deliver a model drug to the endothelium and interstitium of chorioallantoic membrane vasculature in vivo. (E-mail: kwferrara@ucdavis.edu).

Original languageEnglish (US)
Pages (from-to)1771-1780
Number of pages10
JournalUltrasound in Medicine and Biology
Volume32
Issue number11
DOIs
StatePublished - Nov 2006

Fingerprint

Therapeutic Uses
Paclitaxel
Contrast Media
drugs
Pharmaceutical Preparations
delivery
vehicles
endothelium
Chorioallantoic Membrane
Microbubbles
Ultrasonics
Integrins
toxicity
Endothelium
vessels
lipids
Oils
ultrasonics
oils
Radiation

Keywords

  • αβ Acoustically active lipospheres (AALs)
  • Angiogenesis
  • Paclitaxel
  • Radiation force
  • Targeted drug delivery
  • Ultrasound contrast agents

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Tartis, M. S., McCallan, J., Lum, A. F. H., LaBell, R., Stieger, S. M., Matsunaga, T. O., & Ferrara, K. W. (2006). Therapeutic effects of paclitaxel-containing ultrasound contrast agents. Ultrasound in Medicine and Biology, 32(11), 1771-1780. https://doi.org/10.1016/j.ultrasmedbio.2006.03.017

Therapeutic effects of paclitaxel-containing ultrasound contrast agents. / Tartis, Michaelann Shortencarier; McCallan, Jennifer; Lum, Aaron F H; LaBell, Rachel; Stieger, Susanne M.; Matsunaga, Terry O.; Ferrara, Katherine W.

In: Ultrasound in Medicine and Biology, Vol. 32, No. 11, 11.2006, p. 1771-1780.

Research output: Contribution to journalArticle

Tartis, MS, McCallan, J, Lum, AFH, LaBell, R, Stieger, SM, Matsunaga, TO & Ferrara, KW 2006, 'Therapeutic effects of paclitaxel-containing ultrasound contrast agents', Ultrasound in Medicine and Biology, vol. 32, no. 11, pp. 1771-1780. https://doi.org/10.1016/j.ultrasmedbio.2006.03.017
Tartis MS, McCallan J, Lum AFH, LaBell R, Stieger SM, Matsunaga TO et al. Therapeutic effects of paclitaxel-containing ultrasound contrast agents. Ultrasound in Medicine and Biology. 2006 Nov;32(11):1771-1780. https://doi.org/10.1016/j.ultrasmedbio.2006.03.017
Tartis, Michaelann Shortencarier ; McCallan, Jennifer ; Lum, Aaron F H ; LaBell, Rachel ; Stieger, Susanne M. ; Matsunaga, Terry O. ; Ferrara, Katherine W. / Therapeutic effects of paclitaxel-containing ultrasound contrast agents. In: Ultrasound in Medicine and Biology. 2006 ; Vol. 32, No. 11. pp. 1771-1780.
@article{22cf7f026aec40d4b129922c03380aff,
title = "Therapeutic effects of paclitaxel-containing ultrasound contrast agents",
abstract = "Drug delivery vehicles that combine ultrasonic and molecular targeting are shown to locally concentrate a drug in a region-of-interest. The drug delivery vehicles, referred to as acoustically active lipospheres (AALs), are microbubbles surrounded by a shell of oil and lipid. In a region limited to the focal area of ultrasound application, circulating AALs are deflected by radiation force to a vessel wall and can subsequently be fragmented. Ligands targeting the αvβ3 integrin are conjugated to the AAL shell and increase in vitro binding by 26.5-fold over nontargeted agents. Toxicity assays demonstrate that paclitaxel-containing AALs exert a greater antiproliferative effect after insonation than free paclitaxel at an equivalent concentration. Lastly, ultrasound and molecular targeting are combined to deliver a model drug to the endothelium and interstitium of chorioallantoic membrane vasculature in vivo. (E-mail: kwferrara@ucdavis.edu).",
keywords = "αβ Acoustically active lipospheres (AALs), Angiogenesis, Paclitaxel, Radiation force, Targeted drug delivery, Ultrasound contrast agents",
author = "Tartis, {Michaelann Shortencarier} and Jennifer McCallan and Lum, {Aaron F H} and Rachel LaBell and Stieger, {Susanne M.} and Matsunaga, {Terry O.} and Ferrara, {Katherine W.}",
year = "2006",
month = "11",
doi = "10.1016/j.ultrasmedbio.2006.03.017",
language = "English (US)",
volume = "32",
pages = "1771--1780",
journal = "Ultrasound in Medicine and Biology",
issn = "0301-5629",
publisher = "Elsevier USA",
number = "11",

}

TY - JOUR

T1 - Therapeutic effects of paclitaxel-containing ultrasound contrast agents

AU - Tartis, Michaelann Shortencarier

AU - McCallan, Jennifer

AU - Lum, Aaron F H

AU - LaBell, Rachel

AU - Stieger, Susanne M.

AU - Matsunaga, Terry O.

AU - Ferrara, Katherine W.

PY - 2006/11

Y1 - 2006/11

N2 - Drug delivery vehicles that combine ultrasonic and molecular targeting are shown to locally concentrate a drug in a region-of-interest. The drug delivery vehicles, referred to as acoustically active lipospheres (AALs), are microbubbles surrounded by a shell of oil and lipid. In a region limited to the focal area of ultrasound application, circulating AALs are deflected by radiation force to a vessel wall and can subsequently be fragmented. Ligands targeting the αvβ3 integrin are conjugated to the AAL shell and increase in vitro binding by 26.5-fold over nontargeted agents. Toxicity assays demonstrate that paclitaxel-containing AALs exert a greater antiproliferative effect after insonation than free paclitaxel at an equivalent concentration. Lastly, ultrasound and molecular targeting are combined to deliver a model drug to the endothelium and interstitium of chorioallantoic membrane vasculature in vivo. (E-mail: kwferrara@ucdavis.edu).

AB - Drug delivery vehicles that combine ultrasonic and molecular targeting are shown to locally concentrate a drug in a region-of-interest. The drug delivery vehicles, referred to as acoustically active lipospheres (AALs), are microbubbles surrounded by a shell of oil and lipid. In a region limited to the focal area of ultrasound application, circulating AALs are deflected by radiation force to a vessel wall and can subsequently be fragmented. Ligands targeting the αvβ3 integrin are conjugated to the AAL shell and increase in vitro binding by 26.5-fold over nontargeted agents. Toxicity assays demonstrate that paclitaxel-containing AALs exert a greater antiproliferative effect after insonation than free paclitaxel at an equivalent concentration. Lastly, ultrasound and molecular targeting are combined to deliver a model drug to the endothelium and interstitium of chorioallantoic membrane vasculature in vivo. (E-mail: kwferrara@ucdavis.edu).

KW - αβ Acoustically active lipospheres (AALs)

KW - Angiogenesis

KW - Paclitaxel

KW - Radiation force

KW - Targeted drug delivery

KW - Ultrasound contrast agents

UR - http://www.scopus.com/inward/record.url?scp=33750813534&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750813534&partnerID=8YFLogxK

U2 - 10.1016/j.ultrasmedbio.2006.03.017

DO - 10.1016/j.ultrasmedbio.2006.03.017

M3 - Article

C2 - 17112963

AN - SCOPUS:33750813534

VL - 32

SP - 1771

EP - 1780

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

SN - 0301-5629

IS - 11

ER -