Therapeutic approaches for preventing bone loss in inflammatory arthritis

Q. Rehman, Nancy E Lane

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Inflammatory arthritides are commonly characterized by localized and generalized bone loss. Localized bone loss in the form of joint erosions and periarticular osteopenia is a hallmark of rheumatoid arthritis, the prototype of inflammatory arthritis. Recent studies have highlighted the importance of receptor activator of nuclear factor-κB ligand (RANKL)-dependent osteoclast activation by inflammatory cells and subsequent bone loss. In this article, we review the pathogenesis of inflammatory bone loss and explore the possible therapeutic interventions to prevent it.

Original languageEnglish (US)
Pages (from-to)221-227
Number of pages7
JournalArthritis Research
Issue number4
StatePublished - 2001
Externally publishedYes


  • Osteoclast
  • Osteoprotegerin
  • Receptor activator of nuclear factor-ΚB ligand
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Medicine(all)


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