Therapeutic approaches for preventing bone loss in inflammatory arthritis

Q. Rehman, Nancy E Lane

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Inflammatory arthritides are commonly characterized by localized and generalized bone loss. Localized bone loss in the form of joint erosions and periarticular osteopenia is a hallmark of rheumatoid arthritis, the prototype of inflammatory arthritis. Recent studies have highlighted the importance of receptor activator of nuclear factor-κB ligand (RANKL)-dependent osteoclast activation by inflammatory cells and subsequent bone loss. In this article, we review the pathogenesis of inflammatory bone loss and explore the possible therapeutic interventions to prevent it.

Original languageEnglish (US)
Pages (from-to)221-227
Number of pages7
JournalArthritis Research
Volume3
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Arthritis
Bone and Bones
Metabolic Bone Diseases
Osteoclasts
Therapeutics
Cytoplasmic and Nuclear Receptors
Rheumatoid Arthritis
Joints
Ligands

Keywords

  • Osteoclast
  • Osteoprotegerin
  • Receptor activator of nuclear factor-ΚB ligand
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Medicine(all)

Cite this

Therapeutic approaches for preventing bone loss in inflammatory arthritis. / Rehman, Q.; Lane, Nancy E.

In: Arthritis Research, Vol. 3, No. 4, 2001, p. 221-227.

Research output: Contribution to journalArticle

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