The X chromosome in female-predominant autoimmune diseases

Pietro Invernizzi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

20 Citations (Scopus)

Abstract

Autoimmune diseases affect approximately 5% of the population in Western countries, with high female predominance. Family and twins studies have demonstrated that genetic factors are crucial determinants of susceptibility to autoimmune disease, but no specific genes have yet been identified. Recent studies indicate that X chromosome abnormalities, such as monosomy rates and inactivation patterns, occur in a number of female-predominant autoimmune diseases. We will review herein the most recent evidence on the role of the X chromosome in loss of tolerance and discuss its potential implications. Future studies will identify the X chromosome regions containing candidate genes for autoimmune susceptibility.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages57-64
Number of pages8
Volume1110
DOIs
StatePublished - Sep 2007
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1110
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

X Chromosome
Chromosomes
Autoimmune Diseases
Genes
Monosomy
Twin Studies
Chromosome Aberrations
Population

Keywords

  • Autoimmunity
  • Immunopathogenesis
  • Monosomy
  • X chromosome
  • X chromosome inactivation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Invernizzi, P. (2007). The X chromosome in female-predominant autoimmune diseases. In Annals of the New York Academy of Sciences (Vol. 1110, pp. 57-64). (Annals of the New York Academy of Sciences; Vol. 1110). https://doi.org/10.1196/annals.1423.007

The X chromosome in female-predominant autoimmune diseases. / Invernizzi, Pietro.

Annals of the New York Academy of Sciences. Vol. 1110 2007. p. 57-64 (Annals of the New York Academy of Sciences; Vol. 1110).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Invernizzi, P 2007, The X chromosome in female-predominant autoimmune diseases. in Annals of the New York Academy of Sciences. vol. 1110, Annals of the New York Academy of Sciences, vol. 1110, pp. 57-64. https://doi.org/10.1196/annals.1423.007
Invernizzi P. The X chromosome in female-predominant autoimmune diseases. In Annals of the New York Academy of Sciences. Vol. 1110. 2007. p. 57-64. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1423.007
Invernizzi, Pietro. / The X chromosome in female-predominant autoimmune diseases. Annals of the New York Academy of Sciences. Vol. 1110 2007. pp. 57-64 (Annals of the New York Academy of Sciences).
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