Abstract
Autoimmune diseases affect approximately 5% of the population in Western countries, with high female predominance. Family and twins studies have demonstrated that genetic factors are crucial determinants of susceptibility to autoimmune disease, but no specific genes have yet been identified. Recent studies indicate that X chromosome abnormalities, such as monosomy rates and inactivation patterns, occur in a number of female-predominant autoimmune diseases. We will review herein the most recent evidence on the role of the X chromosome in loss of tolerance and discuss its potential implications. Future studies will identify the X chromosome regions containing candidate genes for autoimmune susceptibility.
| Original language | English (US) |
|---|---|
| Title of host publication | Annals of the New York Academy of Sciences |
| Pages | 57-64 |
| Number of pages | 8 |
| Volume | 1110 |
| DOIs | |
| State | Published - Sep 2007 |
| Externally published | Yes |
Publication series
| Name | Annals of the New York Academy of Sciences |
|---|---|
| Volume | 1110 |
| ISSN (Print) | 00778923 |
| ISSN (Electronic) | 17496632 |
Keywords
- Autoimmunity
- Immunopathogenesis
- Monosomy
- X chromosome
- X chromosome inactivation
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Fingerprint Dive into the research topics of 'The X chromosome in female-predominant autoimmune diseases'. Together they form a unique fingerprint.
Cite this
Invernizzi, P. (2007). The X chromosome in female-predominant autoimmune diseases. In Annals of the New York Academy of Sciences (Vol. 1110, pp. 57-64). (Annals of the New York Academy of Sciences; Vol. 1110). https://doi.org/10.1196/annals.1423.007