The virtual electrode hypothesis of defibrillation

Crystal M Ripplinger, Igor R. Efimov

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Despite significant research efforts of investigators in academia, medicine, and the pharmaceutical industry, no effective pharmacological alternative to defibrillation by electric shock has been developed. Thus, defibrillation has evolved to become the only effective therapy against sudden cardiac death. Highly detailed knowledge of ion channel biophysics and cell signaling cascades has allowed for the development of numerous specific agonists and antagonists, but as of yet, has failed to deliver safe and effective antiarrhythmic therapy. In contrast to this approach, electrotherapy is steadily improving its efficacy and safety. Despite major improvements over the past several decades, defibrillation is not free from side effects, which may include both contractile and electrical dysfunction.1-3 In addition to physical damage to the heart, defibrillation is also associated with psychological side effects.4,5 Therefore, reduction of defibrillation energy is highly desirable. However, the basic mechanisms of defibrillation still remain debatable a century after its inception, which has slowed further improvement of the therapy. This chapter explores one of the leading hypotheses of defibrillation, the virtual electrode hypothesis, which has emerged over the past decade through the successes of novel research methodologies, including optical mapping and bidomain modeling.

Original languageEnglish (US)
Title of host publicationCardiac Bioelectric Therapy: Mechanisms and Practical Implications
PublisherSpringer US
Pages331-356
Number of pages26
ISBN (Print)9780387794020
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Electrodes
Electric Stimulation Therapy
Biophysics
Electric Countershock
Sudden Cardiac Death
Drug Industry
Ion Channels
Shock
Research Design
Therapeutics
Research Personnel
Medicine
Pharmacology
Psychology
Safety
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ripplinger, C. M., & Efimov, I. R. (2009). The virtual electrode hypothesis of defibrillation. In Cardiac Bioelectric Therapy: Mechanisms and Practical Implications (pp. 331-356). Springer US. https://doi.org/10.1007/978-0-387-79403-7_13

The virtual electrode hypothesis of defibrillation. / Ripplinger, Crystal M; Efimov, Igor R.

Cardiac Bioelectric Therapy: Mechanisms and Practical Implications. Springer US, 2009. p. 331-356.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ripplinger, CM & Efimov, IR 2009, The virtual electrode hypothesis of defibrillation. in Cardiac Bioelectric Therapy: Mechanisms and Practical Implications. Springer US, pp. 331-356. https://doi.org/10.1007/978-0-387-79403-7_13
Ripplinger CM, Efimov IR. The virtual electrode hypothesis of defibrillation. In Cardiac Bioelectric Therapy: Mechanisms and Practical Implications. Springer US. 2009. p. 331-356 https://doi.org/10.1007/978-0-387-79403-7_13
Ripplinger, Crystal M ; Efimov, Igor R. / The virtual electrode hypothesis of defibrillation. Cardiac Bioelectric Therapy: Mechanisms and Practical Implications. Springer US, 2009. pp. 331-356
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