The vinylogous Witkop cyclisation

Elena L. Ruchkina, Alexander J. Blake, Mark Mascal

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The first example of a vinylogous Witkop cyclisation produces a novel azonino[c,d]indole, a carbocyclic analogue of the tumour-promoting indolactam family of natural products. A similar reaction previously reported to give azecino[c,d]indoles leads only to azocino[c,d]indoles, even when the radical centre is stabilised by the presence of halogens.

Original languageEnglish (US)
Pages (from-to)8443-8445
Number of pages3
JournalTetrahedron Letters
Volume40
Issue number48
DOIs
StatePublished - Nov 26 1999
Externally publishedYes

Keywords

  • Cyclisation
  • Indoles
  • Radical reactions

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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    Ruchkina, E. L., Blake, A. J., & Mascal, M. (1999). The vinylogous Witkop cyclisation. Tetrahedron Letters, 40(48), 8443-8445. https://doi.org/10.1016/S0040-4039(99)01760-8