The vinylogous Witkop cyclisation

Elena L. Ruchkina, Alexander J. Blake, Mark Mascal

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The first example of a vinylogous Witkop cyclisation produces a novel azonino[c,d]indole, a carbocyclic analogue of the tumour-promoting indolactam family of natural products. A similar reaction previously reported to give azecino[c,d]indoles leads only to azocino[c,d]indoles, even when the radical centre is stabilised by the presence of halogens.

Original languageEnglish (US)
Pages (from-to)8443-8445
Number of pages3
JournalTetrahedron Letters
Volume40
Issue number48
DOIs
StatePublished - Nov 26 1999
Externally publishedYes

Fingerprint

Indoles
Cyclization
Halogens
Biological Products
Tumors
Neoplasms
indole

Keywords

  • Cyclisation
  • Indoles
  • Radical reactions

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Ruchkina, E. L., Blake, A. J., & Mascal, M. (1999). The vinylogous Witkop cyclisation. Tetrahedron Letters, 40(48), 8443-8445. https://doi.org/10.1016/S0040-4039(99)01760-8

The vinylogous Witkop cyclisation. / Ruchkina, Elena L.; Blake, Alexander J.; Mascal, Mark.

In: Tetrahedron Letters, Vol. 40, No. 48, 26.11.1999, p. 8443-8445.

Research output: Contribution to journalArticle

Ruchkina, EL, Blake, AJ & Mascal, M 1999, 'The vinylogous Witkop cyclisation', Tetrahedron Letters, vol. 40, no. 48, pp. 8443-8445. https://doi.org/10.1016/S0040-4039(99)01760-8
Ruchkina EL, Blake AJ, Mascal M. The vinylogous Witkop cyclisation. Tetrahedron Letters. 1999 Nov 26;40(48):8443-8445. https://doi.org/10.1016/S0040-4039(99)01760-8
Ruchkina, Elena L. ; Blake, Alexander J. ; Mascal, Mark. / The vinylogous Witkop cyclisation. In: Tetrahedron Letters. 1999 ; Vol. 40, No. 48. pp. 8443-8445.
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