Abstract
The first example of a vinylogous Witkop cyclisation produces a novel azonino[c,d]indole, a carbocyclic analogue of the tumour-promoting indolactam family of natural products. A similar reaction previously reported to give azecino[c,d]indoles leads only to azocino[c,d]indoles, even when the radical centre is stabilised by the presence of halogens.
Original language | English (US) |
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Pages (from-to) | 8443-8445 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 40 |
Issue number | 48 |
DOIs | |
State | Published - Nov 26 1999 |
Externally published | Yes |
Keywords
- Cyclisation
- Indoles
- Radical reactions
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery