Abstract
The first example of a vinylogous Witkop cyclisation produces a novel azonino[c,d]indole, a carbocyclic analogue of the tumour-promoting indolactam family of natural products. A similar reaction previously reported to give azecino[c,d]indoles leads only to azocino[c,d]indoles, even when the radical centre is stabilised by the presence of halogens.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8443-8445 |
| Number of pages | 3 |
| Journal | Tetrahedron Letters |
| Volume | 40 |
| Issue number | 48 |
| DOIs | |
| State | Published - Nov 26 1999 |
| Externally published | Yes |
Keywords
- Cyclisation
- Indoles
- Radical reactions
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
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Cite this
Ruchkina, E. L., Blake, A. J., & Mascal, M. (1999). The vinylogous Witkop cyclisation. Tetrahedron Letters, 40(48), 8443-8445. https://doi.org/10.1016/S0040-4039(99)01760-8