The vinylogous Witkop cyclisation

Elena L. Ruchkina, Alexander J. Blake, Mark Mascal

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The first example of a vinylogous Witkop cyclisation produces a novel azonino[c,d]indole, a carbocyclic analogue of the tumour-promoting indolactam family of natural products. A similar reaction previously reported to give azecino[c,d]indoles leads only to azocino[c,d]indoles, even when the radical centre is stabilised by the presence of halogens.

Original languageEnglish (US)
Pages (from-to)8443-8445
Number of pages3
JournalTetrahedron Letters
Issue number48
StatePublished - Nov 26 1999
Externally publishedYes


  • Cyclisation
  • Indoles
  • Radical reactions

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery


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