The vinylogous Witkop cyclisation

Elena L. Ruchkina; Alexander J. Blake; Mark Mascal

doi:10.1016/S0040-4039(99)01760-8

The vinylogous Witkop cyclisation

Elena L. Ruchkina, Alexander J. Blake, Mark Mascal

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The first example of a vinylogous Witkop cyclisation produces a novel azonino[c,d]indole, a carbocyclic analogue of the tumour-promoting indolactam family of natural products. A similar reaction previously reported to give azecino[c,d]indoles leads only to azocino[c,d]indoles, even when the radical centre is stabilised by the presence of halogens.

Original language	English (US)
Pages (from-to)	8443-8445
Number of pages	3
Journal	Tetrahedron Letters
Volume	40
Issue number	48
DOIs	https://doi.org/10.1016/S0040-4039(99)01760-8
State	Published - Nov 26 1999
Externally published	Yes

Keywords

Cyclisation
Indoles
Radical reactions

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

Access to Document

10.1016/S0040-4039(99)01760-8

Fingerprint Dive into the research topics of 'The vinylogous Witkop cyclisation'. Together they form a unique fingerprint.

Cite this

@article{334db32b9542434b9bdfb59331cacc5a,

title = "The vinylogous Witkop cyclisation",

abstract = "The first example of a vinylogous Witkop cyclisation produces a novel azonino[c,d]indole, a carbocyclic analogue of the tumour-promoting indolactam family of natural products. A similar reaction previously reported to give azecino[c,d]indoles leads only to azocino[c,d]indoles, even when the radical centre is stabilised by the presence of halogens.",

keywords = "Cyclisation, Indoles, Radical reactions",

author = "Ruchkina, {Elena L.} and Blake, {Alexander J.} and Mark Mascal",

year = "1999",

month = nov,

day = "26",

doi = "10.1016/S0040-4039(99)01760-8",

language = "English (US)",

volume = "40",

pages = "8443--8445",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "48",

}

TY - JOUR

T1 - The vinylogous Witkop cyclisation

AU - Ruchkina, Elena L.

AU - Blake, Alexander J.

AU - Mascal, Mark

PY - 1999/11/26

Y1 - 1999/11/26

N2 - The first example of a vinylogous Witkop cyclisation produces a novel azonino[c,d]indole, a carbocyclic analogue of the tumour-promoting indolactam family of natural products. A similar reaction previously reported to give azecino[c,d]indoles leads only to azocino[c,d]indoles, even when the radical centre is stabilised by the presence of halogens.

AB - The first example of a vinylogous Witkop cyclisation produces a novel azonino[c,d]indole, a carbocyclic analogue of the tumour-promoting indolactam family of natural products. A similar reaction previously reported to give azecino[c,d]indoles leads only to azocino[c,d]indoles, even when the radical centre is stabilised by the presence of halogens.

KW - Cyclisation

KW - Indoles

KW - Radical reactions

UR - http://www.scopus.com/inward/record.url?scp=0033607603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033607603&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(99)01760-8

DO - 10.1016/S0040-4039(99)01760-8

M3 - Article

AN - SCOPUS:0033607603

VL - 40

SP - 8443

EP - 8445

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 48

ER -

The vinylogous Witkop cyclisation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this