The ventilatory response to intravenous and ventriculo-cisternal theophylline

J. E. Wick, R. E. DeAtley, T. O. Oei, M. R. Glick, A. Brashear, J. Baenziger, R. E. Brashear

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1 Scopus citations


The stimulatory effect of theophylline on ventilation was studied in nine anesthetized dogs. Theophylline infused intravenously (10 mg/kg bolus, then 1.00 mg/kg/hr) for 210 minutes significantly increased the minute volume of ventilation (P < 0.05 at 210 minutes). After a recovery period of seven to fourteen days, ventriculo-cisternal perfusion was performed with mock cerebrospinal fluid (CSF). Theophylline added to the mock CSF did not significantly change the minute ventilation. Ventriculo-cisternal perfusion utilizing mock CSF not containing theophylline combined with intravenous theophylline infusion stimulated ventilation similarly to the previous intravenous theophylline infusion. Therefore, stimulation of ventilation by theophylline appears to relate to the serum theophylline concentration and not the ventricular CSF theophylline concentration.

Original languageEnglish (US)
Pages (from-to)79-94
Number of pages16
JournalResearch Communications in Chemical Pathology and Pharmacology
Issue number1
StatePublished - Oct 6 1983
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)


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