Abstract
Introduction. Retroperitoneal sarcomas are uncommon large malignant tumors. Methods. Forty-one consecutive patients with localized retroperitoneal sarcoma were retrospectively studied. Results. Median age was 58 years (range 20-91 years). Median tumor size was 17.5cm (range 4-41cm). Only 2 tumors were 5cm. Most were liposarcoma (44) and high-grade (59). 59 were stage 3 and the rest was stage 1. Median followup was 10 months (range 1-106 months). Thirty-eight patients had an initial complete resection; 15 (37) developed recurrent sarcoma and 12 (80) had a second complete resection. Patients with an initial complete resection had a 5-year survival of 46. For all patients, tumor grade affected overall survival (P=.006). Complete surgical resection improved overall survival for high-grade tumors (P=.03). Conclusions. Tumor grade/stage and complete surgical resection for high-grade tumors are important prognostic variables. Radiation therapy or chemotherapy had no significant impact on overall or recurrence-free survival. Complete surgical resection is the treatment of choice for patients with initial and locally recurrent retroperitoneal sarcoma.
| Original language | English (US) |
|---|---|
| Article number | 605840 |
| Journal | Sarcoma |
| Volume | 2009 |
| DOIs | |
| State | Published - Nov 17 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
Cite this
The value of surgery for retroperitoneal sarcoma. / Norton, Jeffrey A.; Gholami, Sepideh; Jacobs, Charlotte D.; Kapp, Daniel S.; Parast, Layla M.
In: Sarcoma, Vol. 2009, 605840, 17.11.2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The value of surgery for retroperitoneal sarcoma
AU - Norton, Jeffrey A.
AU - Gholami, Sepideh
AU - Jacobs, Charlotte D.
AU - Kapp, Daniel S.
AU - Parast, Layla M.
PY - 2009/11/17
Y1 - 2009/11/17
N2 - Introduction. Retroperitoneal sarcomas are uncommon large malignant tumors. Methods. Forty-one consecutive patients with localized retroperitoneal sarcoma were retrospectively studied. Results. Median age was 58 years (range 20-91 years). Median tumor size was 17.5cm (range 4-41cm). Only 2 tumors were 5cm. Most were liposarcoma (44) and high-grade (59). 59 were stage 3 and the rest was stage 1. Median followup was 10 months (range 1-106 months). Thirty-eight patients had an initial complete resection; 15 (37) developed recurrent sarcoma and 12 (80) had a second complete resection. Patients with an initial complete resection had a 5-year survival of 46. For all patients, tumor grade affected overall survival (P=.006). Complete surgical resection improved overall survival for high-grade tumors (P=.03). Conclusions. Tumor grade/stage and complete surgical resection for high-grade tumors are important prognostic variables. Radiation therapy or chemotherapy had no significant impact on overall or recurrence-free survival. Complete surgical resection is the treatment of choice for patients with initial and locally recurrent retroperitoneal sarcoma.
AB - Introduction. Retroperitoneal sarcomas are uncommon large malignant tumors. Methods. Forty-one consecutive patients with localized retroperitoneal sarcoma were retrospectively studied. Results. Median age was 58 years (range 20-91 years). Median tumor size was 17.5cm (range 4-41cm). Only 2 tumors were 5cm. Most were liposarcoma (44) and high-grade (59). 59 were stage 3 and the rest was stage 1. Median followup was 10 months (range 1-106 months). Thirty-eight patients had an initial complete resection; 15 (37) developed recurrent sarcoma and 12 (80) had a second complete resection. Patients with an initial complete resection had a 5-year survival of 46. For all patients, tumor grade affected overall survival (P=.006). Complete surgical resection improved overall survival for high-grade tumors (P=.03). Conclusions. Tumor grade/stage and complete surgical resection for high-grade tumors are important prognostic variables. Radiation therapy or chemotherapy had no significant impact on overall or recurrence-free survival. Complete surgical resection is the treatment of choice for patients with initial and locally recurrent retroperitoneal sarcoma.
UR - http://www.scopus.com/inward/record.url?scp=70449441058&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70449441058&partnerID=8YFLogxK
U2 - 10.1155/2009/605840
DO - 10.1155/2009/605840
M3 - Article
C2 - 19826633
AN - SCOPUS:70449441058
VL - 2009
JO - Sarcoma
JF - Sarcoma
SN - 1357-714X
M1 - 605840
ER -