The utility of IgM, CD21, HGAL and LMO2 in the diagnosis of pediatric follicular lymphoma

Tejashree Karnik, Michael G. Ozawa, Martina Lefterova, Sandra Luna-Fineman, Elysia Alvarez, Michael Link, James L. Zehnder, Daniel A. Arber, Robert S. Ohgami

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Summary Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of pFL, neoplastic B cells within follicles did not express B-cell leukemia/lymphoma 2 (BCL2). However, this case showed additional distinctive abnormal findings, which contributed to the diagnosis: (1) diffuse and uniform staining of immunoglobulin M (IgM) on cells within and outside of follicles, (2) abnormally dim expression of CD21 on follicular dendritic cells, and (3) expression of human germinal center-associated lymphoma (HGAL) and LIM domain only 2 (LMO2) on B cells in interfollicular and follicular areas. This case demonstrates the utility of these abnormal features, which can be seen in adult- or usual-type follicular lymphoma, in the diagnosis of pFL. Further studies are necessary to evaluate the significance of these findings in other cases of pFL.

Original languageEnglish (US)
Pages (from-to)629-633
Number of pages5
JournalHuman Pathology
Volume46
Issue number4
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Follicular Lymphoma
Germinal Center
Immunoglobulin M
Lymphoma
Pediatrics
B-Lymphocytes
Follicular Dendritic Cells
B-Cell Leukemia
B-Cell Lymphoma
Hyperplasia
Staining and Labeling

Keywords

  • Adult follicular lymphoma
  • HGAL
  • IgM
  • LMO2
  • Pediatric follicular lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Karnik, T., Ozawa, M. G., Lefterova, M., Luna-Fineman, S., Alvarez, E., Link, M., ... Ohgami, R. S. (2015). The utility of IgM, CD21, HGAL and LMO2 in the diagnosis of pediatric follicular lymphoma. Human Pathology, 46(4), 629-633. https://doi.org/10.1016/j.humpath.2014.12.016

The utility of IgM, CD21, HGAL and LMO2 in the diagnosis of pediatric follicular lymphoma. / Karnik, Tejashree; Ozawa, Michael G.; Lefterova, Martina; Luna-Fineman, Sandra; Alvarez, Elysia; Link, Michael; Zehnder, James L.; Arber, Daniel A.; Ohgami, Robert S.

In: Human Pathology, Vol. 46, No. 4, 01.01.2015, p. 629-633.

Research output: Contribution to journalArticle

Karnik, T, Ozawa, MG, Lefterova, M, Luna-Fineman, S, Alvarez, E, Link, M, Zehnder, JL, Arber, DA & Ohgami, RS 2015, 'The utility of IgM, CD21, HGAL and LMO2 in the diagnosis of pediatric follicular lymphoma', Human Pathology, vol. 46, no. 4, pp. 629-633. https://doi.org/10.1016/j.humpath.2014.12.016
Karnik, Tejashree ; Ozawa, Michael G. ; Lefterova, Martina ; Luna-Fineman, Sandra ; Alvarez, Elysia ; Link, Michael ; Zehnder, James L. ; Arber, Daniel A. ; Ohgami, Robert S. / The utility of IgM, CD21, HGAL and LMO2 in the diagnosis of pediatric follicular lymphoma. In: Human Pathology. 2015 ; Vol. 46, No. 4. pp. 629-633.
@article{c3742b0ea6734b869ecb93ab1f4480a2,
title = "The utility of IgM, CD21, HGAL and LMO2 in the diagnosis of pediatric follicular lymphoma",
abstract = "Summary Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of pFL, neoplastic B cells within follicles did not express B-cell leukemia/lymphoma 2 (BCL2). However, this case showed additional distinctive abnormal findings, which contributed to the diagnosis: (1) diffuse and uniform staining of immunoglobulin M (IgM) on cells within and outside of follicles, (2) abnormally dim expression of CD21 on follicular dendritic cells, and (3) expression of human germinal center-associated lymphoma (HGAL) and LIM domain only 2 (LMO2) on B cells in interfollicular and follicular areas. This case demonstrates the utility of these abnormal features, which can be seen in adult- or usual-type follicular lymphoma, in the diagnosis of pFL. Further studies are necessary to evaluate the significance of these findings in other cases of pFL.",
keywords = "Adult follicular lymphoma, HGAL, IgM, LMO2, Pediatric follicular lymphoma",
author = "Tejashree Karnik and Ozawa, {Michael G.} and Martina Lefterova and Sandra Luna-Fineman and Elysia Alvarez and Michael Link and Zehnder, {James L.} and Arber, {Daniel A.} and Ohgami, {Robert S.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/j.humpath.2014.12.016",
language = "English (US)",
volume = "46",
pages = "629--633",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - The utility of IgM, CD21, HGAL and LMO2 in the diagnosis of pediatric follicular lymphoma

AU - Karnik, Tejashree

AU - Ozawa, Michael G.

AU - Lefterova, Martina

AU - Luna-Fineman, Sandra

AU - Alvarez, Elysia

AU - Link, Michael

AU - Zehnder, James L.

AU - Arber, Daniel A.

AU - Ohgami, Robert S.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Summary Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of pFL, neoplastic B cells within follicles did not express B-cell leukemia/lymphoma 2 (BCL2). However, this case showed additional distinctive abnormal findings, which contributed to the diagnosis: (1) diffuse and uniform staining of immunoglobulin M (IgM) on cells within and outside of follicles, (2) abnormally dim expression of CD21 on follicular dendritic cells, and (3) expression of human germinal center-associated lymphoma (HGAL) and LIM domain only 2 (LMO2) on B cells in interfollicular and follicular areas. This case demonstrates the utility of these abnormal features, which can be seen in adult- or usual-type follicular lymphoma, in the diagnosis of pFL. Further studies are necessary to evaluate the significance of these findings in other cases of pFL.

AB - Summary Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of pFL, neoplastic B cells within follicles did not express B-cell leukemia/lymphoma 2 (BCL2). However, this case showed additional distinctive abnormal findings, which contributed to the diagnosis: (1) diffuse and uniform staining of immunoglobulin M (IgM) on cells within and outside of follicles, (2) abnormally dim expression of CD21 on follicular dendritic cells, and (3) expression of human germinal center-associated lymphoma (HGAL) and LIM domain only 2 (LMO2) on B cells in interfollicular and follicular areas. This case demonstrates the utility of these abnormal features, which can be seen in adult- or usual-type follicular lymphoma, in the diagnosis of pFL. Further studies are necessary to evaluate the significance of these findings in other cases of pFL.

KW - Adult follicular lymphoma

KW - HGAL

KW - IgM

KW - LMO2

KW - Pediatric follicular lymphoma

UR - http://www.scopus.com/inward/record.url?scp=84925685705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925685705&partnerID=8YFLogxK

U2 - 10.1016/j.humpath.2014.12.016

DO - 10.1016/j.humpath.2014.12.016

M3 - Article

C2 - 25701230

AN - SCOPUS:84925685705

VL - 46

SP - 629

EP - 633

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 4

ER -