Abstract
Summary Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of pFL, neoplastic B cells within follicles did not express B-cell leukemia/lymphoma 2 (BCL2). However, this case showed additional distinctive abnormal findings, which contributed to the diagnosis: (1) diffuse and uniform staining of immunoglobulin M (IgM) on cells within and outside of follicles, (2) abnormally dim expression of CD21 on follicular dendritic cells, and (3) expression of human germinal center-associated lymphoma (HGAL) and LIM domain only 2 (LMO2) on B cells in interfollicular and follicular areas. This case demonstrates the utility of these abnormal features, which can be seen in adult- or usual-type follicular lymphoma, in the diagnosis of pFL. Further studies are necessary to evaluate the significance of these findings in other cases of pFL.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 629-633 |
| Number of pages | 5 |
| Journal | Human Pathology |
| Volume | 46 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 2015 |
| Externally published | Yes |
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Keywords
- Adult follicular lymphoma
- HGAL
- IgM
- LMO2
- Pediatric follicular lymphoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
The utility of IgM, CD21, HGAL and LMO2 in the diagnosis of pediatric follicular lymphoma. / Karnik, Tejashree; Ozawa, Michael G.; Lefterova, Martina; Luna-Fineman, Sandra; Alvarez, Elysia; Link, Michael; Zehnder, James L.; Arber, Daniel A.; Ohgami, Robert S.
In: Human Pathology, Vol. 46, No. 4, 01.01.2015, p. 629-633.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The utility of IgM, CD21, HGAL and LMO2 in the diagnosis of pediatric follicular lymphoma
AU - Karnik, Tejashree
AU - Ozawa, Michael G.
AU - Lefterova, Martina
AU - Luna-Fineman, Sandra
AU - Alvarez, Elysia
AU - Link, Michael
AU - Zehnder, James L.
AU - Arber, Daniel A.
AU - Ohgami, Robert S.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Summary Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of pFL, neoplastic B cells within follicles did not express B-cell leukemia/lymphoma 2 (BCL2). However, this case showed additional distinctive abnormal findings, which contributed to the diagnosis: (1) diffuse and uniform staining of immunoglobulin M (IgM) on cells within and outside of follicles, (2) abnormally dim expression of CD21 on follicular dendritic cells, and (3) expression of human germinal center-associated lymphoma (HGAL) and LIM domain only 2 (LMO2) on B cells in interfollicular and follicular areas. This case demonstrates the utility of these abnormal features, which can be seen in adult- or usual-type follicular lymphoma, in the diagnosis of pFL. Further studies are necessary to evaluate the significance of these findings in other cases of pFL.
AB - Summary Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of pFL, neoplastic B cells within follicles did not express B-cell leukemia/lymphoma 2 (BCL2). However, this case showed additional distinctive abnormal findings, which contributed to the diagnosis: (1) diffuse and uniform staining of immunoglobulin M (IgM) on cells within and outside of follicles, (2) abnormally dim expression of CD21 on follicular dendritic cells, and (3) expression of human germinal center-associated lymphoma (HGAL) and LIM domain only 2 (LMO2) on B cells in interfollicular and follicular areas. This case demonstrates the utility of these abnormal features, which can be seen in adult- or usual-type follicular lymphoma, in the diagnosis of pFL. Further studies are necessary to evaluate the significance of these findings in other cases of pFL.
KW - Adult follicular lymphoma
KW - HGAL
KW - IgM
KW - LMO2
KW - Pediatric follicular lymphoma
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UR - http://www.scopus.com/inward/citedby.url?scp=84925685705&partnerID=8YFLogxK
U2 - 10.1016/j.humpath.2014.12.016
DO - 10.1016/j.humpath.2014.12.016
M3 - Article
C2 - 25701230
AN - SCOPUS:84925685705
VL - 46
SP - 629
EP - 633
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 4
ER -