The utility of IgM, CD21, HGAL and LMO2 in the diagnosis of pediatric follicular lymphoma

Tejashree Karnik, Michael G. Ozawa, Martina Lefterova, Sandra Luna-Fineman, Elysia Alvarez, Michael Link, James L. Zehnder, Daniel A. Arber, Robert S. Ohgami

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Summary Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of pFL, neoplastic B cells within follicles did not express B-cell leukemia/lymphoma 2 (BCL2). However, this case showed additional distinctive abnormal findings, which contributed to the diagnosis: (1) diffuse and uniform staining of immunoglobulin M (IgM) on cells within and outside of follicles, (2) abnormally dim expression of CD21 on follicular dendritic cells, and (3) expression of human germinal center-associated lymphoma (HGAL) and LIM domain only 2 (LMO2) on B cells in interfollicular and follicular areas. This case demonstrates the utility of these abnormal features, which can be seen in adult- or usual-type follicular lymphoma, in the diagnosis of pFL. Further studies are necessary to evaluate the significance of these findings in other cases of pFL.

Original languageEnglish (US)
Pages (from-to)629-633
Number of pages5
JournalHuman Pathology
Volume46
Issue number4
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Adult follicular lymphoma
  • HGAL
  • IgM
  • LMO2
  • Pediatric follicular lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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  • Cite this

    Karnik, T., Ozawa, M. G., Lefterova, M., Luna-Fineman, S., Alvarez, E., Link, M., Zehnder, J. L., Arber, D. A., & Ohgami, R. S. (2015). The utility of IgM, CD21, HGAL and LMO2 in the diagnosis of pediatric follicular lymphoma. Human Pathology, 46(4), 629-633. https://doi.org/10.1016/j.humpath.2014.12.016