Abstract
Summary Pediatric follicular lymphoma (pFL) is a rare neoplasm with features differing from follicular lymphoma arising in adults. Here, we describe a rare case of pFL that showed morphologic features partially overlapping with progressive transformation of germinal centers and reactive follicular hyperplasia. As typical of pFL, neoplastic B cells within follicles did not express B-cell leukemia/lymphoma 2 (BCL2). However, this case showed additional distinctive abnormal findings, which contributed to the diagnosis: (1) diffuse and uniform staining of immunoglobulin M (IgM) on cells within and outside of follicles, (2) abnormally dim expression of CD21 on follicular dendritic cells, and (3) expression of human germinal center-associated lymphoma (HGAL) and LIM domain only 2 (LMO2) on B cells in interfollicular and follicular areas. This case demonstrates the utility of these abnormal features, which can be seen in adult- or usual-type follicular lymphoma, in the diagnosis of pFL. Further studies are necessary to evaluate the significance of these findings in other cases of pFL.
Original language | English (US) |
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Pages (from-to) | 629-633 |
Number of pages | 5 |
Journal | Human Pathology |
Volume | 46 |
Issue number | 4 |
DOIs | |
State | Published - Jan 1 2015 |
Externally published | Yes |
Keywords
- Adult follicular lymphoma
- HGAL
- IgM
- LMO2
- Pediatric follicular lymphoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine