The use of topical Nitrosomonas eutropha for cosmetic improvement of facial wrinkles

Manisha Notay, Suzana Saric-Bosanac, Alexandra R. Vaughn, Simran Dhaliwal, Megha Trivedi, Paloma N. Reiter, Iryna Rybak, Connie C. Li, Larry B. Weiss, Lauren Ambrogio, Waqas Burney, Raja K Sivamani

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background: Both topical and oral probiotics are becoming widely used. There is increasing interest in the cosmetic potential in topical probiotics. Nitrosomonas eutropha is an ammonia-oxidizing bacteria. Aim: The purpose of this study was to assess whether there is any improvement in facial wrinkles with the use of Nitrosomonas eutropha, a topical probiotic. Methods: In this prospective study, high-resolution photographs were obtained in twenty-nine participants at baseline and after using topical Nitrosomonas eutropha for seven days. Results: There was a significant difference in wrinkle depth and severity in the high concentration probiotic group. There was also a statistically significant improvement in pigmentation of the forehead and glabella in the higher concentration group. Conclusions: Nitrosomonas eutropha may have aesthetic benefits in terms of reducing the appearance of wrinkles. Larger studies with longer treatment and follow-up periods are required.

Original languageEnglish (US)
JournalJournal of Cosmetic Dermatology
StatePublished - Jan 1 2019


  • photography
  • pigmentation
  • probiotics
  • wrinkles

ASJC Scopus subject areas

  • Dermatology


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