The use of parenteral clindamycin in the treatment of obstetric gynecologic patients with severe infections. A comparison of a clindamycin kanamycin combination with penicillin kanamycin

W. J. Ledger, T. J. Kriewall, Richard L Sweet, F. R. Fekety

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Using a system of random selection in patients with severe obstetric gynecologic infections, parenteral penicillin kanamycin was given to 23 women and clindamycin kanamycin was given to 21. Therapeutic response to the two antibiotic regimens was similar; no significant differences were noted in either the posttreatment fever index or the numbers of women requiring other therapy. There was a failure of response to the penicillin kanamycin regimen in those women with Bacteroides fragilis infection and to the clindamycin kanamycin regimen in some of the women with an Enterococcus infection. The implications of these findings for the future selection of antibiotics for patients with severe obstetric gynecologic infections are discussed.

Original languageEnglish (US)
Pages (from-to)490-497
Number of pages8
JournalObstetrics and Gynecology
Volume43
Issue number4
StatePublished - 1974
Externally publishedYes

Fingerprint

Kanamycin
Clindamycin
Penicillins
Obstetrics
Infection
Patient Selection
Bacteroides Infections
Anti-Bacterial Agents
Bacteroides fragilis
Enterococcus
Therapeutics
Fever

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

@article{5599957bd4fb40049131eefc2cdc5fa3,
title = "The use of parenteral clindamycin in the treatment of obstetric gynecologic patients with severe infections. A comparison of a clindamycin kanamycin combination with penicillin kanamycin",
abstract = "Using a system of random selection in patients with severe obstetric gynecologic infections, parenteral penicillin kanamycin was given to 23 women and clindamycin kanamycin was given to 21. Therapeutic response to the two antibiotic regimens was similar; no significant differences were noted in either the posttreatment fever index or the numbers of women requiring other therapy. There was a failure of response to the penicillin kanamycin regimen in those women with Bacteroides fragilis infection and to the clindamycin kanamycin regimen in some of the women with an Enterococcus infection. The implications of these findings for the future selection of antibiotics for patients with severe obstetric gynecologic infections are discussed.",
author = "Ledger, {W. J.} and Kriewall, {T. J.} and Sweet, {Richard L} and Fekety, {F. R.}",
year = "1974",
language = "English (US)",
volume = "43",
pages = "490--497",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - The use of parenteral clindamycin in the treatment of obstetric gynecologic patients with severe infections. A comparison of a clindamycin kanamycin combination with penicillin kanamycin

AU - Ledger, W. J.

AU - Kriewall, T. J.

AU - Sweet, Richard L

AU - Fekety, F. R.

PY - 1974

Y1 - 1974

N2 - Using a system of random selection in patients with severe obstetric gynecologic infections, parenteral penicillin kanamycin was given to 23 women and clindamycin kanamycin was given to 21. Therapeutic response to the two antibiotic regimens was similar; no significant differences were noted in either the posttreatment fever index or the numbers of women requiring other therapy. There was a failure of response to the penicillin kanamycin regimen in those women with Bacteroides fragilis infection and to the clindamycin kanamycin regimen in some of the women with an Enterococcus infection. The implications of these findings for the future selection of antibiotics for patients with severe obstetric gynecologic infections are discussed.

AB - Using a system of random selection in patients with severe obstetric gynecologic infections, parenteral penicillin kanamycin was given to 23 women and clindamycin kanamycin was given to 21. Therapeutic response to the two antibiotic regimens was similar; no significant differences were noted in either the posttreatment fever index or the numbers of women requiring other therapy. There was a failure of response to the penicillin kanamycin regimen in those women with Bacteroides fragilis infection and to the clindamycin kanamycin regimen in some of the women with an Enterococcus infection. The implications of these findings for the future selection of antibiotics for patients with severe obstetric gynecologic infections are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0015965331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015965331&partnerID=8YFLogxK

M3 - Article

C2 - 4593619

AN - SCOPUS:0015965331

VL - 43

SP - 490

EP - 497

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 4

ER -