The use of one-bead one-compound combinatorial library method to identify peptide ligands for α4β1 integrin receptor in non-Hodgkin's lymphoma

Steven I. Park, Manat Renil, Brian Vikstrom, Nail Amro, Liang wen Song, Bai ling Xu, Kit Lam

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Using a 'one-bead one-compound' combinatorial library method and whole cell binding assay, we have identified peptide ligands that bind preferentially to human lymphoid malignant cells but not to normal human peripheral lymphocytes. These peptides have a common motif of Leu-Asp-Ile, Leu-Asp-Phe, or Leu-Asp-Val. Anti-α4 integrin antibody blocks binding of cells to these peptides which indicates that the target receptor for these peptides is α4β1 integrin. These findings may have important therapeutic and diagnostic implications in the treatment of lymphoma, leukemia, and various immunologic disorders.

Original languageEnglish (US)
Pages (from-to)171-178
Number of pages8
JournalLetters in Peptide Science
Volume8
Issue number3-5
DOIs
StatePublished - 2002

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Keywords

  • Cancer therapy
  • Cell-adhesion
  • Combinatorial chemistry
  • Integrin
  • Non-Hodgkin lymphoma
  • Targeted-therapy

ASJC Scopus subject areas

  • Biochemistry

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