Abstract
Using a 'one-bead one-compound' combinatorial library method and whole cell binding assay, we have identified peptide ligands that bind preferentially to human lymphoid malignant cells but not to normal human peripheral lymphocytes. These peptides have a common motif of Leu-Asp-Ile, Leu-Asp-Phe, or Leu-Asp-Val. Anti-α4 integrin antibody blocks binding of cells to these peptides which indicates that the target receptor for these peptides is α4β1 integrin. These findings may have important therapeutic and diagnostic implications in the treatment of lymphoma, leukemia, and various immunologic disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 171-178 |
| Number of pages | 8 |
| Journal | Letters in Peptide Science |
| Volume | 8 |
| Issue number | 3-5 |
| DOIs | |
| State | Published - 2002 |
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Keywords
- Cancer therapy
- Cell-adhesion
- Combinatorial chemistry
- Integrin
- Non-Hodgkin lymphoma
- Targeted-therapy
ASJC Scopus subject areas
- Biochemistry
Cite this
The use of one-bead one-compound combinatorial library method to identify peptide ligands for α4β1 integrin receptor in non-Hodgkin's lymphoma. / Park, Steven I.; Renil, Manat; Vikstrom, Brian; Amro, Nail; Song, Liang wen; Xu, Bai ling; Lam, Kit.
In: Letters in Peptide Science, Vol. 8, No. 3-5, 2002, p. 171-178.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The use of one-bead one-compound combinatorial library method to identify peptide ligands for α4β1 integrin receptor in non-Hodgkin's lymphoma
AU - Park, Steven I.
AU - Renil, Manat
AU - Vikstrom, Brian
AU - Amro, Nail
AU - Song, Liang wen
AU - Xu, Bai ling
AU - Lam, Kit
PY - 2002
Y1 - 2002
N2 - Using a 'one-bead one-compound' combinatorial library method and whole cell binding assay, we have identified peptide ligands that bind preferentially to human lymphoid malignant cells but not to normal human peripheral lymphocytes. These peptides have a common motif of Leu-Asp-Ile, Leu-Asp-Phe, or Leu-Asp-Val. Anti-α4 integrin antibody blocks binding of cells to these peptides which indicates that the target receptor for these peptides is α4β1 integrin. These findings may have important therapeutic and diagnostic implications in the treatment of lymphoma, leukemia, and various immunologic disorders.
AB - Using a 'one-bead one-compound' combinatorial library method and whole cell binding assay, we have identified peptide ligands that bind preferentially to human lymphoid malignant cells but not to normal human peripheral lymphocytes. These peptides have a common motif of Leu-Asp-Ile, Leu-Asp-Phe, or Leu-Asp-Val. Anti-α4 integrin antibody blocks binding of cells to these peptides which indicates that the target receptor for these peptides is α4β1 integrin. These findings may have important therapeutic and diagnostic implications in the treatment of lymphoma, leukemia, and various immunologic disorders.
KW - Cancer therapy
KW - Cell-adhesion
KW - Combinatorial chemistry
KW - Integrin
KW - Non-Hodgkin lymphoma
KW - Targeted-therapy
UR - http://www.scopus.com/inward/record.url?scp=0036330488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036330488&partnerID=8YFLogxK
U2 - 10.1023/A:1016297601361
DO - 10.1023/A:1016297601361
M3 - Article
VL - 8
SP - 171
EP - 178
JO - International Journal of Peptide Research and Therapeutics
JF - International Journal of Peptide Research and Therapeutics
SN - 1573-3149
IS - 3-5
ER -