The use of molecular hybridization techniques as tools to evaluate hepatic fibrogenesis

Mark A Zern, Mark J. Czaja, Francis R. Weiner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Collagens are a heterogeneous group of proteins that make up a major portion of the extracellular matrix in addition to proteoglycans and noncollagenous glycoproteins. There are at least ten types of collagens, for which constituent chains are coded by a minimum of 17 genes. 1-5 The collagens are briefly described in Tables 1 through 3 as they have been grouped by Miller. 6 This chapter will attempt to delineate two elements which are crucial to the understanding of collagen synthesis: the level of gene regulation responsible for changes in collagen content and factors that affect collagen gene expression.

Original languageEnglish (US)
Title of host publicationConnective Tissue in Health and Disease
PublisherCRC Press
Pages99-122
Number of pages24
ISBN (Electronic)9781351367318
ISBN (Print)9781138506787
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Zern, M. A., Czaja, M. J., & Weiner, F. R. (2017). The use of molecular hybridization techniques as tools to evaluate hepatic fibrogenesis. In Connective Tissue in Health and Disease (pp. 99-122). CRC Press. https://doi.org/10.1201/9781315150512