Abstract
Collagens are a heterogeneous group of proteins that make up a major portion of the extracellular matrix in addition to proteoglycans and noncollagenous glycoproteins. There are at least ten types of collagens, for which constituent chains are coded by a minimum of 17 genes. 1-5 The collagens are briefly described in Tables 1 through 3 as they have been grouped by Miller. 6 This chapter will attempt to delineate two elements which are crucial to the understanding of collagen synthesis: the level of gene regulation responsible for changes in collagen content and factors that affect collagen gene expression.
| Original language | English (US) |
|---|---|
| Title of host publication | Connective Tissue in Health and Disease |
| Publisher | CRC Press |
| Pages | 99-122 |
| Number of pages | 24 |
| ISBN (Electronic) | 9781351367318 |
| ISBN (Print) | 9781138506787 |
| DOIs | |
| State | Published - Jan 1 2017 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Zern, M. A., Czaja, M. J., & Weiner, F. R. (2017). The use of molecular hybridization techniques as tools to evaluate hepatic fibrogenesis. In Connective Tissue in Health and Disease (pp. 99-122). CRC Press. https://doi.org/10.1201/9781315150512