The use of molecular hybridization techniques as tools to evaluate hepatic fibrogenesis

Mark A Zern; Mark J. Czaja; Francis R. Weiner

doi:10.1201/9781315150512

The use of molecular hybridization techniques as tools to evaluate hepatic fibrogenesis

Mark A Zern, Mark J. Czaja, Francis R. Weiner

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Collagens are a heterogeneous group of proteins that make up a major portion of the extracellular matrix in addition to proteoglycans and noncollagenous glycoproteins. There are at least ten types of collagens, for which constituent chains are coded by a minimum of 17 genes. ^1-5 The collagens are briefly described in Tables 1 through 3 as they have been grouped by Miller. ⁶ This chapter will attempt to delineate two elements which are crucial to the understanding of collagen synthesis: the level of gene regulation responsible for changes in collagen content and factors that affect collagen gene expression.

Original language	English (US)
Title of host publication	Connective Tissue in Health and Disease
Publisher	CRC Press
Pages	99-122
Number of pages	24
ISBN (Electronic)	9781351367318
ISBN (Print)	9781138506787
DOIs	https://doi.org/10.1201/9781315150512
State	Published - Jan 1 2017
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

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