Abstract
Collagens are a heterogeneous group of proteins that make up a major portion of the extracellular matrix in addition to proteoglycans and noncollagenous glycoproteins. There are at least ten types of collagens, for which constituent chains are coded by a minimum of 17 genes. 1-5 The collagens are briefly described in Tables 1 through 3 as they have been grouped by Miller. 6 This chapter will attempt to delineate two elements which are crucial to the understanding of collagen synthesis: the level of gene regulation responsible for changes in collagen content and factors that affect collagen gene expression.
| Original language | English (US) |
|---|---|
| Title of host publication | Connective Tissue in Health and Disease |
| Publisher | CRC Press |
| Pages | 99-122 |
| Number of pages | 24 |
| ISBN (Electronic) | 9781351367318 |
| ISBN (Print) | 9781138506787 |
| DOIs | |
| State | Published - Jan 1 2017 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
The use of molecular hybridization techniques as tools to evaluate hepatic fibrogenesis. / Zern, Mark A; Czaja, Mark J.; Weiner, Francis R.
Connective Tissue in Health and Disease. CRC Press, 2017. p. 99-122.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - The use of molecular hybridization techniques as tools to evaluate hepatic fibrogenesis
AU - Zern, Mark A
AU - Czaja, Mark J.
AU - Weiner, Francis R.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Collagens are a heterogeneous group of proteins that make up a major portion of the extracellular matrix in addition to proteoglycans and noncollagenous glycoproteins. There are at least ten types of collagens, for which constituent chains are coded by a minimum of 17 genes. 1-5 The collagens are briefly described in Tables 1 through 3 as they have been grouped by Miller. 6 This chapter will attempt to delineate two elements which are crucial to the understanding of collagen synthesis: the level of gene regulation responsible for changes in collagen content and factors that affect collagen gene expression.
AB - Collagens are a heterogeneous group of proteins that make up a major portion of the extracellular matrix in addition to proteoglycans and noncollagenous glycoproteins. There are at least ten types of collagens, for which constituent chains are coded by a minimum of 17 genes. 1-5 The collagens are briefly described in Tables 1 through 3 as they have been grouped by Miller. 6 This chapter will attempt to delineate two elements which are crucial to the understanding of collagen synthesis: the level of gene regulation responsible for changes in collagen content and factors that affect collagen gene expression.
UR - http://www.scopus.com/inward/record.url?scp=0343469550&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0343469550&partnerID=8YFLogxK
U2 - 10.1201/9781315150512
DO - 10.1201/9781315150512
M3 - Chapter
AN - SCOPUS:0343469550
SN - 9781138506787
SP - 99
EP - 122
BT - Connective Tissue in Health and Disease
PB - CRC Press
ER -