Collagens are a heterogeneous group of proteins that make up a major portion of the extracellular matrix in addition to proteoglycans and noncollagenous glycoproteins. There are at least ten types of collagens, for which constituent chains are coded by a minimum of 17 genes. 1-5 The collagens are briefly described in Tables 1 through 3 as they have been grouped by Miller. 6 This chapter will attempt to delineate two elements which are crucial to the understanding of collagen synthesis: the level of gene regulation responsible for changes in collagen content and factors that affect collagen gene expression.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)