The use of a non-specific defence mechanism inducer in calves exposed to bovine herpesvirus-1 infection: Preliminary trials

G. Castrucci, M. Ferrari, Bennie Osburn, F. Frigeri, F. Barreca, S. Tagliati, V. Cuteri

Research output: Contribution to journalArticle

13 Scopus citations


The efficacy of an immunomodulator, the Baypamun (Bayer AG), was tested in calves which were subsequently exposed to bovine herpesvirus-1 (BHV-1) infection. Two groups of calves, of 8 animals each, were used for two trials. In one trial, 4 calves were treated with the immunomodulator and the remaining 4 were left as untreated controls. Two hours after the first injection of Baypamun, all calves, i.e. the treated and the untreated ones, were challenged with BHV-1. Comparing them to the untreated controls, the calves which were given the immunomodulator developed milder signs of the disease and shed a significantly lower concentration of virus. In the second experiment, 4 calves were given Baypamun and 4 calves were not, as above, but they were not inoculated with BHV-1; however, they were housed together with the calves of the former group (experimentally infected with BHV-1). The 8 calves all became infected but those that had been treated with Baypamun did not show any clinical signs of the disease, whereas the untreated calves underwent a clinical response which was considered to be typical of BHV-1 respiratory infection, as usually seen under natural conditions. In this case the shedding of virus by the calves treated with the immunomodulator also underwent a significant reduction.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalComparative Immunology, Microbiology and Infectious Diseases
Issue number2
StatePublished - Jan 1 1995



  • bovine herpesvirus-1
  • calves
  • Immunomodulator

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • veterinary(all)
  • Infectious Diseases

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