The two major isoforms of thyroid hormone receptor, TRα1 and TRβ1, preferentially partner with distinct panels of auxiliary proteins

Johnnie B. Hahm; Amy C. Schroeder; Martin L. Privalsky

doi:10.1016/j.mce.2013.11.015

The two major isoforms of thyroid hormone receptor, TRα1 and TRβ1, preferentially partner with distinct panels of auxiliary proteins

Johnnie B. Hahm, Amy C. Schroeder, Martin L. Privalsky

Microbiology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Thyroid hormone receptors (TRs) are expressed primarily as two major isoforms, TRα1 and TRβ1, which are expressed at different times in development and at different tissue abundances in the adult. The transcription properties and biological properties of TRα1 and TRβ1 can differ. We report here that although overlapping, TRα1 and TRβ1 recruit distinct panels of partner proteins that may account for their divergent biological functions, and which appear to explain their distinct target gene regulatory properties.

Original language	English (US)
Pages (from-to)	80-95
Number of pages	16
Journal	Molecular and Cellular Endocrinology
Volume	383
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mce.2013.11.015
State	Published - Mar 5 2014

Keywords

Coactivators
Corepressors
Isoforms
Nuclear receptor partner proteins
Thyroid hormone receptors
Transcriptional regulation

ASJC Scopus subject areas

Endocrinology
Molecular Biology
Biochemistry

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10.1016/j.mce.2013.11.015

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abstract = "Thyroid hormone receptors (TRs) are expressed primarily as two major isoforms, TRα1 and TRβ1, which are expressed at different times in development and at different tissue abundances in the adult. The transcription properties and biological properties of TRα1 and TRβ1 can differ. We report here that although overlapping, TRα1 and TRβ1 recruit distinct panels of partner proteins that may account for their divergent biological functions, and which appear to explain their distinct target gene regulatory properties.",

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AU - Schroeder, Amy C.

AU - Privalsky, Martin L.

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AB - Thyroid hormone receptors (TRs) are expressed primarily as two major isoforms, TRα1 and TRβ1, which are expressed at different times in development and at different tissue abundances in the adult. The transcription properties and biological properties of TRα1 and TRβ1 can differ. We report here that although overlapping, TRα1 and TRβ1 recruit distinct panels of partner proteins that may account for their divergent biological functions, and which appear to explain their distinct target gene regulatory properties.

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KW - Corepressors

KW - Isoforms

KW - Nuclear receptor partner proteins

KW - Thyroid hormone receptors

KW - Transcriptional regulation

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The two major isoforms of thyroid hormone receptor, TRα1 and TRβ1, preferentially partner with distinct panels of auxiliary proteins

Abstract

Keywords

ASJC Scopus subject areas

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