Abstract
Thyroid hormone receptors (TRs) are expressed primarily as two major isoforms, TRα1 and TRβ1, which are expressed at different times in development and at different tissue abundances in the adult. The transcription properties and biological properties of TRα1 and TRβ1 can differ. We report here that although overlapping, TRα1 and TRβ1 recruit distinct panels of partner proteins that may account for their divergent biological functions, and which appear to explain their distinct target gene regulatory properties.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 80-95 |
| Number of pages | 16 |
| Journal | Molecular and Cellular Endocrinology |
| Volume | 383 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Mar 5 2014 |
Fingerprint
Keywords
- Coactivators
- Corepressors
- Isoforms
- Nuclear receptor partner proteins
- Thyroid hormone receptors
- Transcriptional regulation
ASJC Scopus subject areas
- Endocrinology
- Molecular Biology
- Biochemistry
Cite this
The two major isoforms of thyroid hormone receptor, TRα1 and TRβ1, preferentially partner with distinct panels of auxiliary proteins. / Hahm, Johnnie B.; Schroeder, Amy C.; Privalsky, Martin L.
In: Molecular and Cellular Endocrinology, Vol. 383, No. 1-2, 05.03.2014, p. 80-95.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The two major isoforms of thyroid hormone receptor, TRα1 and TRβ1, preferentially partner with distinct panels of auxiliary proteins
AU - Hahm, Johnnie B.
AU - Schroeder, Amy C.
AU - Privalsky, Martin L.
PY - 2014/3/5
Y1 - 2014/3/5
N2 - Thyroid hormone receptors (TRs) are expressed primarily as two major isoforms, TRα1 and TRβ1, which are expressed at different times in development and at different tissue abundances in the adult. The transcription properties and biological properties of TRα1 and TRβ1 can differ. We report here that although overlapping, TRα1 and TRβ1 recruit distinct panels of partner proteins that may account for their divergent biological functions, and which appear to explain their distinct target gene regulatory properties.
AB - Thyroid hormone receptors (TRs) are expressed primarily as two major isoforms, TRα1 and TRβ1, which are expressed at different times in development and at different tissue abundances in the adult. The transcription properties and biological properties of TRα1 and TRβ1 can differ. We report here that although overlapping, TRα1 and TRβ1 recruit distinct panels of partner proteins that may account for their divergent biological functions, and which appear to explain their distinct target gene regulatory properties.
KW - Coactivators
KW - Corepressors
KW - Isoforms
KW - Nuclear receptor partner proteins
KW - Thyroid hormone receptors
KW - Transcriptional regulation
UR - http://www.scopus.com/inward/record.url?scp=84891131423&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891131423&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2013.11.015
DO - 10.1016/j.mce.2013.11.015
M3 - Article
C2 - 24325866
AN - SCOPUS:84891131423
VL - 383
SP - 80
EP - 95
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - 1-2
ER -