The tumor pathology of genetically engineered mice: Genomic pathology

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter examines a newly emerging view of tumorigenesis by exploring the evidence that the molecular origin of the tumor determines the microscopic phenotype of the tumor. It is primarily based on the genetically engineered mice (GEM) expressing transgenic oncogenes or lacking homologs of human tumor-suppressor genes. The current data supporting this hypothesis are based primarily on mouse models of human prostate and breast cancers, but additional evidence is provided from other organ systems. The data demonstrate that the molecular origins of tumors create unique signature phenotypes that belong to distinct molecular pathways. The members of each pathway display unique interrelationships and dependencies. Many of the signature phenotypes mimic human tumor morphology in incredible detail and often represent involvement of the same genes. The pathology of tumorigenesis in GEM has important implications for human and comparative pathology.

Original languageEnglish (US)
Title of host publicationGenetically Engineered Mice for Cancer Research
Subtitle of host publicationDesign, Analysis, Pathways, Validation and Pre-Clinical Testing
PublisherSpringer New York
Pages133-180
Number of pages48
ISBN (Electronic)9780387698052
ISBN (Print)9780387698038
DOIs
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Cardiff, R. (2012). The tumor pathology of genetically engineered mice: Genomic pathology. In Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing (pp. 133-180). Springer New York. https://doi.org/10.1007/978-0-387-69805-2_7