The transcriptional repressor Snail promotes mammary tumor recurrence

Susan E. Moody, Denise Perez, Tien Chi Pan, Christopher J. Sarkisian, Carla P. Portocarrero, Christopher J. Sterner, Kathleen L. Notorfrancesco, Robert Cardiff, Lewis A. Chodosh

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Abstract

Breast cancer recurrence is a fundamental clinical manifestation of tumor progression and represents the principal cause of death from this disease. Using a conditional transgenic mouse model for the recurrence of HER2/neu-induced mammary tumors, we demonstrate that the transcriptional repressor Snail is spontaneously upregulated in recurrent tumors in vivo and that recurrence is accompanied by epithelial-to-mesenchymal transition (EMT). Consistent with a causal role for Snail in these processes, we show that Snail is sufficient to induce EMT in primary tumor cells, that Snail is sufficient to promote mammary tumor recurrence in vivo, and that high levels of Snail predict decreased relapse-free survival in women with breast cancer. In aggregate, our observations strongly implicate Snail in the process of breast cancer recurrence.

Original languageEnglish (US)
Pages (from-to)197-209
Number of pages13
JournalCancer Cell
Volume8
Issue number3
DOIs
StatePublished - Sep 1 2005

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ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this

Moody, S. E., Perez, D., Pan, T. C., Sarkisian, C. J., Portocarrero, C. P., Sterner, C. J., Notorfrancesco, K. L., Cardiff, R., & Chodosh, L. A. (2005). The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell, 8(3), 197-209. https://doi.org/10.1016/j.ccr.2005.07.009