The training stimulus experienced by the leg muscles during cycling in humans

Jamie S. McPhee, Alun G. Williams, Claire Stewart, Keith Baar, Joaquin Perez Schindler, Sarah Aldred, Nicola Maffulli, Anthony J. Sargeant, David A. Jones

Research output: Contribution to journalArticle

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Abstract

Considerable variability exists between people in their health- and performance-related adaptations to conventional endurance training. We hypothesized that some of this variability might be due to differences in the training stimulus received by the working muscles. In 71 young sedentary women we observed large variations in the ratio of one-leg cycling muscle aerobic capacity to two-leg cycling whole-body maximal oxygen uptake (; Ratio 1:2; range 0.58-0.96). The variability in Ratio1:2 was primarily due to differences between people in one-leg (r = 0.71, P < 0.0005) and was not related to two-leg (r = 0.15, P = 0.209). Magnetic resonance imaging (n = 30) and muscle biopsy sampling (n = 20) revealed that one-leg was mainly determined by muscle volume (r = 0.73, P < 0.0005) rather than muscle fibre type or oxidative capacity. A high one-leg was associated with favourable lipoprotein profiles (P = 0.033, n = 24) but this was not the case for two-leg. Calculations based on these data suggest that conventional two-leg exercise at 70% requires subjects with the lowest Ratio1:2 to work their legs at 60% of single-leg, whilst those with the highest Ratio1:2 work their legs at only 36% of maximum. It was concluded that endurance training carried out according to current guidelines will result in highly variable training stimuli for the leg muscles and variable magnitudes of adaptation. These conclusions have implications for the prescription of exercise to improve health and for investigations into the genetic basis of muscle adaptations.

Original languageEnglish (US)
Pages (from-to)684-694
Number of pages11
JournalExperimental Physiology
Volume94
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

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Leg
Muscles
Exercise
Health
Lipoproteins
Prescriptions
Magnetic Resonance Imaging
Guidelines
Oxygen
Biopsy

ASJC Scopus subject areas

  • Physiology

Cite this

McPhee, J. S., Williams, A. G., Stewart, C., Baar, K., Schindler, J. P., Aldred, S., ... Jones, D. A. (2009). The training stimulus experienced by the leg muscles during cycling in humans. Experimental Physiology, 94(6), 684-694. https://doi.org/10.1113/expphysiol.2008.045658

The training stimulus experienced by the leg muscles during cycling in humans. / McPhee, Jamie S.; Williams, Alun G.; Stewart, Claire; Baar, Keith; Schindler, Joaquin Perez; Aldred, Sarah; Maffulli, Nicola; Sargeant, Anthony J.; Jones, David A.

In: Experimental Physiology, Vol. 94, No. 6, 06.2009, p. 684-694.

Research output: Contribution to journalArticle

McPhee, JS, Williams, AG, Stewart, C, Baar, K, Schindler, JP, Aldred, S, Maffulli, N, Sargeant, AJ & Jones, DA 2009, 'The training stimulus experienced by the leg muscles during cycling in humans', Experimental Physiology, vol. 94, no. 6, pp. 684-694. https://doi.org/10.1113/expphysiol.2008.045658
McPhee JS, Williams AG, Stewart C, Baar K, Schindler JP, Aldred S et al. The training stimulus experienced by the leg muscles during cycling in humans. Experimental Physiology. 2009 Jun;94(6):684-694. https://doi.org/10.1113/expphysiol.2008.045658
McPhee, Jamie S. ; Williams, Alun G. ; Stewart, Claire ; Baar, Keith ; Schindler, Joaquin Perez ; Aldred, Sarah ; Maffulli, Nicola ; Sargeant, Anthony J. ; Jones, David A. / The training stimulus experienced by the leg muscles during cycling in humans. In: Experimental Physiology. 2009 ; Vol. 94, No. 6. pp. 684-694.
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