The tissue is the issue: Personalized medicine for non-small cell lung cancer

Fred R. Hirsch; Murry W. Wynes; David R Gandara; Paul A. Bunn

doi:10.1158/1078-0432.CCR-10-2005

The tissue is the issue: Personalized medicine for non-small cell lung cancer

Fred R. Hirsch, Murry W. Wynes, David R Gandara, Paul A. Bunn

Hematology and Oncology

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

The development of molecular markers is crucial for improving therapy in advanced non-small cell lung cancer (NSCLC). Here, we review perspectives of biomarker-driven personalized therapy in NSCLC, with particular reference to the detection of EML4-ALK gene rearrangements. Different molecular assays, validation, and clinical application to different types of tissue specimens are discussed.

Original language	English (US)
Pages (from-to)	4909-4911
Number of pages	3
Journal	Clinical Cancer Research
Volume	16
Issue number	20
DOIs	https://doi.org/10.1158/1078-0432.CCR-10-2005
State	Published - Oct 15 2010

ASJC Scopus subject areas

Cancer Research
Oncology

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abstract = "The development of molecular markers is crucial for improving therapy in advanced non-small cell lung cancer (NSCLC). Here, we review perspectives of biomarker-driven personalized therapy in NSCLC, with particular reference to the detection of EML4-ALK gene rearrangements. Different molecular assays, validation, and clinical application to different types of tissue specimens are discussed.",

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