The tip of the iceberg: Clinical implications of genomic sequencing projects in head and neck cancer

Andrew C. Birkeland, Megan L. Ludwig, Taha S. Meraj, J. Chad Brenner, Mark E. Prince

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Recent genomic sequencing studies have provided valuable insight into genetic aberrations in head and neck squamous cell carcinoma. Despite these great advances, certain hurdles exist in translating genomic findings to clinical care. Further correlation of genetic findings to clinical outcomes, additional analyses of subgroups of head and neck cancers and follow-up investigation into genetic heterogeneity are needed. While the development of targeted therapy trials is of key importance, numerous challenges exist in establishing and optimizing such programs. This review discusses potential upcoming steps for further genetic evaluation of head and neck cancers and implementation of genetic findings into precision medicine trials.

Original languageEnglish (US)
Pages (from-to)2094-2109
Number of pages16
JournalCancers
Volume7
Issue number4
DOIs
StatePublished - Oct 21 2015
Externally publishedYes

Keywords

  • Cancer
  • Genomic
  • HNSCC
  • Personalized medicine
  • Precision medicine
  • Targeted therapy
  • TCGA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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