The thyroid hormone-induced tail resorption program during Xenopus laevis metamorphosis

Donald D. Brown, Zhou Wang, John Furlow, Akira Kanamori, Robert A. Schwartzman, Benjamin F. Remo, Allison Pinder

Research output: Contribution to journalArticle

211 Citations (Scopus)

Abstract

Genes that are up- and down-regulated by thyroid hormone in the tail resorption program of Xenopus laevis have been isolated by a gene expression screen, sequenced, and identified in the GenBank data base. The entire program is estimated to consist of fewer than 35 up-regulated and fewer than 10 down-regulated genes; 17 and 4 of them, respectively, have been isolated and characterized. Up-regulated genes whose function can be predicted on the basis of their sequence include four transcription factors (including one of the thyroid hormone receptors), an extracellular matrix component (fibronectin) and membrane receptor (integrin), four proteinases, a deiodinase that degrades thyroid hormone, and a protein that binds the hypothalamic corticotropin-releasing factor, which has been implicated in controlling thyroid hormone synthesis in Xenopus tadpoles. All four down- regulated genes encode extracellular proteins that are expressed in tadpole epidermis. This survey of the program provides insights into the biology of metamorphosis.

Original languageEnglish (US)
Pages (from-to)1924-1929
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume93
Issue number5
DOIs
StatePublished - Mar 5 1996
Externally publishedYes

Fingerprint

Xenopus laevis
Thyroid Hormones
Tail
Genes
Larva
Integrin alpha5beta1
Pituitary Hormone-Releasing Hormones
Thyroid Hormone Receptors
Iodide Peroxidase
Corticotropin-Releasing Hormone
Nucleic Acid Databases
Xenopus
Epidermis
Integrins
Extracellular Matrix
Proteins
Transcription Factors
Databases
Gene Expression
Membranes

ASJC Scopus subject areas

  • General

Cite this

The thyroid hormone-induced tail resorption program during Xenopus laevis metamorphosis. / Brown, Donald D.; Wang, Zhou; Furlow, John; Kanamori, Akira; Schwartzman, Robert A.; Remo, Benjamin F.; Pinder, Allison.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, No. 5, 05.03.1996, p. 1924-1929.

Research output: Contribution to journalArticle

Brown, Donald D. ; Wang, Zhou ; Furlow, John ; Kanamori, Akira ; Schwartzman, Robert A. ; Remo, Benjamin F. ; Pinder, Allison. / The thyroid hormone-induced tail resorption program during Xenopus laevis metamorphosis. In: Proceedings of the National Academy of Sciences of the United States of America. 1996 ; Vol. 93, No. 5. pp. 1924-1929.
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