Abstract
The thrombospondins are a family of proteins found widely in the embryonic extracellular matrix. Like most matrix proteins, thrombospondins are modular and contain a series of repeated domains arrayed between globular amino and carboxyl terminal domains. In recent years, other proteins that share thrombospondin type 1 repeats, or TSRs, have been identified. These include the F-spondin gene family, the members of the semaphorin 5 family, UNC-5, SCO-spondin, and others. Most of these are expressed in the developing nervous system, and many have expression patterns and in vitro properties that suggest potential roles in the guidance of cell and growth cone migration. Both cell- and matrix-binding motifs have been identified in the TSRs of thrombospondin-1, so it has been hypothesized that the properties of these diverse proteins may also depend on the presence of these repeats. Here, we review the cell biology of the TSR module, the extensive literature regarding the distribution and functions of thrombospondins and other TSR superfamily proteins, and evaluate their possible roles during the development of the nervous system. (C) 2000 Wiley-Liss, Inc.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 280-299 |
| Number of pages | 20 |
| Journal | Developmental Dynamics |
| Volume | 218 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2000 |
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Keywords
- Brain
- Cell migration
- Extracellular matrix
- F-spondin
- Neural crest
- Semaphorin
- Spinal cord
- Thrombospondin
- UNC- 5
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology
Cite this
The thrombospondin type 1 repeat (TSR) superfamily : Diverse proteins with related roles in neuronal development. / Adams, Josephine C.; Tucker, Richard P.
In: Developmental Dynamics, Vol. 218, No. 2, 2000, p. 280-299.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The thrombospondin type 1 repeat (TSR) superfamily
T2 - Diverse proteins with related roles in neuronal development
AU - Adams, Josephine C.
AU - Tucker, Richard P
PY - 2000
Y1 - 2000
N2 - The thrombospondins are a family of proteins found widely in the embryonic extracellular matrix. Like most matrix proteins, thrombospondins are modular and contain a series of repeated domains arrayed between globular amino and carboxyl terminal domains. In recent years, other proteins that share thrombospondin type 1 repeats, or TSRs, have been identified. These include the F-spondin gene family, the members of the semaphorin 5 family, UNC-5, SCO-spondin, and others. Most of these are expressed in the developing nervous system, and many have expression patterns and in vitro properties that suggest potential roles in the guidance of cell and growth cone migration. Both cell- and matrix-binding motifs have been identified in the TSRs of thrombospondin-1, so it has been hypothesized that the properties of these diverse proteins may also depend on the presence of these repeats. Here, we review the cell biology of the TSR module, the extensive literature regarding the distribution and functions of thrombospondins and other TSR superfamily proteins, and evaluate their possible roles during the development of the nervous system. (C) 2000 Wiley-Liss, Inc.
AB - The thrombospondins are a family of proteins found widely in the embryonic extracellular matrix. Like most matrix proteins, thrombospondins are modular and contain a series of repeated domains arrayed between globular amino and carboxyl terminal domains. In recent years, other proteins that share thrombospondin type 1 repeats, or TSRs, have been identified. These include the F-spondin gene family, the members of the semaphorin 5 family, UNC-5, SCO-spondin, and others. Most of these are expressed in the developing nervous system, and many have expression patterns and in vitro properties that suggest potential roles in the guidance of cell and growth cone migration. Both cell- and matrix-binding motifs have been identified in the TSRs of thrombospondin-1, so it has been hypothesized that the properties of these diverse proteins may also depend on the presence of these repeats. Here, we review the cell biology of the TSR module, the extensive literature regarding the distribution and functions of thrombospondins and other TSR superfamily proteins, and evaluate their possible roles during the development of the nervous system. (C) 2000 Wiley-Liss, Inc.
KW - Brain
KW - Cell migration
KW - Extracellular matrix
KW - F-spondin
KW - Neural crest
KW - Semaphorin
KW - Spinal cord
KW - Thrombospondin
KW - UNC- 5
UR - http://www.scopus.com/inward/record.url?scp=0034074901&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034074901&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-0177(200006)218:2<280::AID-DVDY4>3.0.CO;2-0
DO - 10.1002/(SICI)1097-0177(200006)218:2<280::AID-DVDY4>3.0.CO;2-0
M3 - Article
C2 - 10842357
AN - SCOPUS:0034074901
VL - 218
SP - 280
EP - 299
JO - Developmental Dynamics
JF - Developmental Dynamics
SN - 1058-8388
IS - 2
ER -