The thrombospondin type 1 repeat superfamily

Research output: Contribution to journalArticle

119 Scopus citations

Abstract

The TSR superfamily is a diverse family of extracellular matrix and transmembrane proteins, many of which have functions related to regulating matrix organization, cell-cell interactions and cell guidance. This review samples some of the contemporary literature regarding TSR superfamily members (e.g. F-spondin, UNC-5, ADAMTS, papilin, and TRAP) where specific functions are assigned to the TSR domains. Combining these observations with the published crystal structure of the TSRs of thrombospondin-1 may hold a key to the development of therapeutic agents for fighting parasitic infection and tumor growth.

Original languageEnglish (US)
Pages (from-to)969-974
Number of pages6
JournalInternational Journal of Biochemistry and Cell Biology
Volume36
Issue number6
DOIs
StatePublished - Jun 2004

Keywords

  • Angiogenesis
  • Cell adhesion
  • Cell motility
  • Extracellular matrix

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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