Abstract
Interneurons of the cerebral cortex represent a heterogeneous population of cells with important roles in network function. At present, little is known about how these neurons are specified in the developing telencephalon. To explore whether this diversity is established in the early progenitor populations, we conducted in utero fate-mapping of the mouse medial and caudal ganglionic eminences (MGE and CGE, respectively), from which most cortical interneurons arise. Mature interneuron subtypes were assessed by electrophysiological and immunological analysis, as well as by morphological reconstruction. At E13.5, the MGE gives rise to fast-spiking (FS) interneurons, whereas the CGE generates predominantly regular-spiking interneurons (RSNP). Later at E15.5, the CGE produces RSNP classes distinct from those generated from the E13.5 CGE. Thus, we provide evidence that the spatial and temporal origin of interneuron precursors in the developing telencephalic eminences predicts the intrinsic physiological properties of mature interneurons.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 591-604 |
| Number of pages | 14 |
| Journal | Neuron |
| Volume | 48 |
| Issue number | 4 |
| DOIs | |
| State | Published - Nov 23 2005 |
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ASJC Scopus subject areas
- Neuroscience(all)
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The temporal and spatial origins of cortical interneurons predict their physiological subtype. / Butt, Simon J B; Fuccillo, Marc; Nery, Susana; Noctor, Stephen C; Kriegstein, Arnold; Corbin, Joshua G.; Fishell, Gord.
In: Neuron, Vol. 48, No. 4, 23.11.2005, p. 591-604.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The temporal and spatial origins of cortical interneurons predict their physiological subtype
AU - Butt, Simon J B
AU - Fuccillo, Marc
AU - Nery, Susana
AU - Noctor, Stephen C
AU - Kriegstein, Arnold
AU - Corbin, Joshua G.
AU - Fishell, Gord
PY - 2005/11/23
Y1 - 2005/11/23
N2 - Interneurons of the cerebral cortex represent a heterogeneous population of cells with important roles in network function. At present, little is known about how these neurons are specified in the developing telencephalon. To explore whether this diversity is established in the early progenitor populations, we conducted in utero fate-mapping of the mouse medial and caudal ganglionic eminences (MGE and CGE, respectively), from which most cortical interneurons arise. Mature interneuron subtypes were assessed by electrophysiological and immunological analysis, as well as by morphological reconstruction. At E13.5, the MGE gives rise to fast-spiking (FS) interneurons, whereas the CGE generates predominantly regular-spiking interneurons (RSNP). Later at E15.5, the CGE produces RSNP classes distinct from those generated from the E13.5 CGE. Thus, we provide evidence that the spatial and temporal origin of interneuron precursors in the developing telencephalic eminences predicts the intrinsic physiological properties of mature interneurons.
AB - Interneurons of the cerebral cortex represent a heterogeneous population of cells with important roles in network function. At present, little is known about how these neurons are specified in the developing telencephalon. To explore whether this diversity is established in the early progenitor populations, we conducted in utero fate-mapping of the mouse medial and caudal ganglionic eminences (MGE and CGE, respectively), from which most cortical interneurons arise. Mature interneuron subtypes were assessed by electrophysiological and immunological analysis, as well as by morphological reconstruction. At E13.5, the MGE gives rise to fast-spiking (FS) interneurons, whereas the CGE generates predominantly regular-spiking interneurons (RSNP). Later at E15.5, the CGE produces RSNP classes distinct from those generated from the E13.5 CGE. Thus, we provide evidence that the spatial and temporal origin of interneuron precursors in the developing telencephalic eminences predicts the intrinsic physiological properties of mature interneurons.
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UR - http://www.scopus.com/inward/citedby.url?scp=27844432222&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2005.09.034
DO - 10.1016/j.neuron.2005.09.034
M3 - Article
C2 - 16301176
AN - SCOPUS:27844432222
VL - 48
SP - 591
EP - 604
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 4
ER -