The syntenic relationship of the zebrafish and human genomes [1]

W. Bradley Barbazuk, Ian F Korf, Candy Kadavi, Joshua Heyen, Stephanie Tate, Edmund Wun, Joseph A. Bedell, John Douglas Mcpherson, Stephen L. Johnson

Research output: Contribution to journalArticle

362 Citations (Scopus)

Abstract

The zebrafish is an important vertebrate model for the mutational analysis of genes effecting developmental processes. Understanding the relationship between zebrafish genes and mutations with those of humans will require understanding the syntenic correspondence between the zebrafish and human genomes. High throughput gene and EST mapping projects in zebrafish are now facilitating this goal. Map positions for 523 zebrafish genes and ESTs with predicted human orthologs reveal extensive contiguous blocks of synteny between the zebrafish and human genomes. Eighty percent of genes and ESTs analyzed belong to conserved synteny groups (two or more genes linked in both zebrafish and human) and 56% of all genes analyzed fall in 118 homology segments (uninterrupted segments containing two or more contiguous genes or ESTs with conserved map order between the zebrafish and human genomes). This work now provides a syntenic relationship to the human genome for the majority of the zebrafish genome.

Original languageEnglish (US)
Pages (from-to)1351-1358
Number of pages8
JournalGenome Research
Volume10
Issue number9
DOIs
StatePublished - 2000
Externally publishedYes

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Zebrafish
Human Genome
Expressed Sequence Tags
Genes
Synteny
Developmental Genes
Chromosome Mapping
Vertebrates
Genome
Mutation

ASJC Scopus subject areas

  • Genetics

Cite this

Barbazuk, W. B., Korf, I. F., Kadavi, C., Heyen, J., Tate, S., Wun, E., ... Johnson, S. L. (2000). The syntenic relationship of the zebrafish and human genomes [1]. Genome Research, 10(9), 1351-1358. https://doi.org/10.1101/gr.144700

The syntenic relationship of the zebrafish and human genomes [1]. / Barbazuk, W. Bradley; Korf, Ian F; Kadavi, Candy; Heyen, Joshua; Tate, Stephanie; Wun, Edmund; Bedell, Joseph A.; Mcpherson, John Douglas; Johnson, Stephen L.

In: Genome Research, Vol. 10, No. 9, 2000, p. 1351-1358.

Research output: Contribution to journalArticle

Barbazuk, WB, Korf, IF, Kadavi, C, Heyen, J, Tate, S, Wun, E, Bedell, JA, Mcpherson, JD & Johnson, SL 2000, 'The syntenic relationship of the zebrafish and human genomes [1]', Genome Research, vol. 10, no. 9, pp. 1351-1358. https://doi.org/10.1101/gr.144700
Barbazuk, W. Bradley ; Korf, Ian F ; Kadavi, Candy ; Heyen, Joshua ; Tate, Stephanie ; Wun, Edmund ; Bedell, Joseph A. ; Mcpherson, John Douglas ; Johnson, Stephen L. / The syntenic relationship of the zebrafish and human genomes [1]. In: Genome Research. 2000 ; Vol. 10, No. 9. pp. 1351-1358.
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