The syntenic relationship of the zebrafish and human genomes [1]

W. Bradley Barbazuk, Ian F Korf, Candy Kadavi, Joshua Heyen, Stephanie Tate, Edmund Wun, Joseph A. Bedell, John Douglas Mcpherson, Stephen L. Johnson

Research output: Contribution to journalArticle

384 Scopus citations

Abstract

The zebrafish is an important vertebrate model for the mutational analysis of genes effecting developmental processes. Understanding the relationship between zebrafish genes and mutations with those of humans will require understanding the syntenic correspondence between the zebrafish and human genomes. High throughput gene and EST mapping projects in zebrafish are now facilitating this goal. Map positions for 523 zebrafish genes and ESTs with predicted human orthologs reveal extensive contiguous blocks of synteny between the zebrafish and human genomes. Eighty percent of genes and ESTs analyzed belong to conserved synteny groups (two or more genes linked in both zebrafish and human) and 56% of all genes analyzed fall in 118 homology segments (uninterrupted segments containing two or more contiguous genes or ESTs with conserved map order between the zebrafish and human genomes). This work now provides a syntenic relationship to the human genome for the majority of the zebrafish genome.

Original languageEnglish (US)
Pages (from-to)1351-1358
Number of pages8
JournalGenome Research
Volume10
Issue number9
DOIs
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'The syntenic relationship of the zebrafish and human genomes [1]'. Together they form a unique fingerprint.

  • Cite this

    Barbazuk, W. B., Korf, I. F., Kadavi, C., Heyen, J., Tate, S., Wun, E., Bedell, J. A., Mcpherson, J. D., & Johnson, S. L. (2000). The syntenic relationship of the zebrafish and human genomes [1]. Genome Research, 10(9), 1351-1358. https://doi.org/10.1101/gr.144700