Abstract
The zebrafish is an important vertebrate model for the mutational analysis of genes effecting developmental processes. Understanding the relationship between zebrafish genes and mutations with those of humans will require understanding the syntenic correspondence between the zebrafish and human genomes. High throughput gene and EST mapping projects in zebrafish are now facilitating this goal. Map positions for 523 zebrafish genes and ESTs with predicted human orthologs reveal extensive contiguous blocks of synteny between the zebrafish and human genomes. Eighty percent of genes and ESTs analyzed belong to conserved synteny groups (two or more genes linked in both zebrafish and human) and 56% of all genes analyzed fall in 118 homology segments (uninterrupted segments containing two or more contiguous genes or ESTs with conserved map order between the zebrafish and human genomes). This work now provides a syntenic relationship to the human genome for the majority of the zebrafish genome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1351-1358 |
| Number of pages | 8 |
| Journal | Genome Research |
| Volume | 10 |
| Issue number | 9 |
| DOIs | |
| State | Published - 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
Cite this
The syntenic relationship of the zebrafish and human genomes [1]. / Barbazuk, W. Bradley; Korf, Ian F; Kadavi, Candy; Heyen, Joshua; Tate, Stephanie; Wun, Edmund; Bedell, Joseph A.; Mcpherson, John Douglas; Johnson, Stephen L.
In: Genome Research, Vol. 10, No. 9, 2000, p. 1351-1358.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The syntenic relationship of the zebrafish and human genomes [1]
AU - Barbazuk, W. Bradley
AU - Korf, Ian F
AU - Kadavi, Candy
AU - Heyen, Joshua
AU - Tate, Stephanie
AU - Wun, Edmund
AU - Bedell, Joseph A.
AU - Mcpherson, John Douglas
AU - Johnson, Stephen L.
PY - 2000
Y1 - 2000
N2 - The zebrafish is an important vertebrate model for the mutational analysis of genes effecting developmental processes. Understanding the relationship between zebrafish genes and mutations with those of humans will require understanding the syntenic correspondence between the zebrafish and human genomes. High throughput gene and EST mapping projects in zebrafish are now facilitating this goal. Map positions for 523 zebrafish genes and ESTs with predicted human orthologs reveal extensive contiguous blocks of synteny between the zebrafish and human genomes. Eighty percent of genes and ESTs analyzed belong to conserved synteny groups (two or more genes linked in both zebrafish and human) and 56% of all genes analyzed fall in 118 homology segments (uninterrupted segments containing two or more contiguous genes or ESTs with conserved map order between the zebrafish and human genomes). This work now provides a syntenic relationship to the human genome for the majority of the zebrafish genome.
AB - The zebrafish is an important vertebrate model for the mutational analysis of genes effecting developmental processes. Understanding the relationship between zebrafish genes and mutations with those of humans will require understanding the syntenic correspondence between the zebrafish and human genomes. High throughput gene and EST mapping projects in zebrafish are now facilitating this goal. Map positions for 523 zebrafish genes and ESTs with predicted human orthologs reveal extensive contiguous blocks of synteny between the zebrafish and human genomes. Eighty percent of genes and ESTs analyzed belong to conserved synteny groups (two or more genes linked in both zebrafish and human) and 56% of all genes analyzed fall in 118 homology segments (uninterrupted segments containing two or more contiguous genes or ESTs with conserved map order between the zebrafish and human genomes). This work now provides a syntenic relationship to the human genome for the majority of the zebrafish genome.
UR - http://www.scopus.com/inward/record.url?scp=0033799583&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033799583&partnerID=8YFLogxK
U2 - 10.1101/gr.144700
DO - 10.1101/gr.144700
M3 - Article
C2 - 10984453
AN - SCOPUS:0033799583
VL - 10
SP - 1351
EP - 1358
JO - Genome Research
JF - Genome Research
SN - 1088-9051
IS - 9
ER -