The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q

Ann M. Saunders; Michael F Seldin

doi:10.1016/0888-7543(90)90573-D

The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q

Ann M. Saunders, Michael F Seldin

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The syntenic relationship of the myotonic dystrophy (DM) gene region on human chromosome 19q and proximal mouse chromosome 7 was examined using an interspecific backcross between C3H/HeJ- gld gld mice and Mus spretus. Segregation analyses were used to order homologs of nine human loci linked were the DM gene. Their order from the centromere was Prkcg, [Apoe, Atpa-2, Ckmm, D19S19h, Ercc-2], Cyp2b, Mag. Lhb. Two other murine loci, D7Rp2 and Ngfg, were also positioned within this interval. Homologs for five human chromosome 11 and 15 loci (Calc, Fes, Hras-1, Igflr, Tyr) were localized within an 18-cM span telomeric to Lhb. Comparison of the gene orders indicates an inversion extending from Prkcg through the interval between Mag and Lhb. This study establishes a detailed map of proximal mouse chromosome 7 that will be useful in identifying and determining whether new human chromosome 19 probes are linked to the DM region.

Original language	English (US)
Pages (from-to)	324-332
Number of pages	9
Journal	Genomics
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/0888-7543(90)90573-D
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Genetics

Access to Document

10.1016/0888-7543(90)90573-D

Fingerprint Dive into the research topics of 'The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q'. Together they form a unique fingerprint.

Cite this

@article{b96ee6689e084d268ea2b0e16a84e1f5,

title = "The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q",

abstract = "The syntenic relationship of the myotonic dystrophy (DM) gene region on human chromosome 19q and proximal mouse chromosome 7 was examined using an interspecific backcross between C3H/HeJ- gld gld mice and Mus spretus. Segregation analyses were used to order homologs of nine human loci linked were the DM gene. Their order from the centromere was Prkcg, [Apoe, Atpa-2, Ckmm, D19S19h, Ercc-2], Cyp2b, Mag. Lhb. Two other murine loci, D7Rp2 and Ngfg, were also positioned within this interval. Homologs for five human chromosome 11 and 15 loci (Calc, Fes, Hras-1, Igflr, Tyr) were localized within an 18-cM span telomeric to Lhb. Comparison of the gene orders indicates an inversion extending from Prkcg through the interval between Mag and Lhb. This study establishes a detailed map of proximal mouse chromosome 7 that will be useful in identifying and determining whether new human chromosome 19 probes are linked to the DM region.",

author = "Saunders, {Ann M.} and Seldin, {Michael F}",

year = "1990",

doi = "10.1016/0888-7543(90)90573-D",

language = "English (US)",

volume = "6",

pages = "324--332",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q

AU - Saunders, Ann M.

AU - Seldin, Michael F

PY - 1990

Y1 - 1990

N2 - The syntenic relationship of the myotonic dystrophy (DM) gene region on human chromosome 19q and proximal mouse chromosome 7 was examined using an interspecific backcross between C3H/HeJ- gld gld mice and Mus spretus. Segregation analyses were used to order homologs of nine human loci linked were the DM gene. Their order from the centromere was Prkcg, [Apoe, Atpa-2, Ckmm, D19S19h, Ercc-2], Cyp2b, Mag. Lhb. Two other murine loci, D7Rp2 and Ngfg, were also positioned within this interval. Homologs for five human chromosome 11 and 15 loci (Calc, Fes, Hras-1, Igflr, Tyr) were localized within an 18-cM span telomeric to Lhb. Comparison of the gene orders indicates an inversion extending from Prkcg through the interval between Mag and Lhb. This study establishes a detailed map of proximal mouse chromosome 7 that will be useful in identifying and determining whether new human chromosome 19 probes are linked to the DM region.

AB - The syntenic relationship of the myotonic dystrophy (DM) gene region on human chromosome 19q and proximal mouse chromosome 7 was examined using an interspecific backcross between C3H/HeJ- gld gld mice and Mus spretus. Segregation analyses were used to order homologs of nine human loci linked were the DM gene. Their order from the centromere was Prkcg, [Apoe, Atpa-2, Ckmm, D19S19h, Ercc-2], Cyp2b, Mag. Lhb. Two other murine loci, D7Rp2 and Ngfg, were also positioned within this interval. Homologs for five human chromosome 11 and 15 loci (Calc, Fes, Hras-1, Igflr, Tyr) were localized within an 18-cM span telomeric to Lhb. Comparison of the gene orders indicates an inversion extending from Prkcg through the interval between Mag and Lhb. This study establishes a detailed map of proximal mouse chromosome 7 that will be useful in identifying and determining whether new human chromosome 19 probes are linked to the DM region.

UR - http://www.scopus.com/inward/record.url?scp=0025279070&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025279070&partnerID=8YFLogxK

U2 - 10.1016/0888-7543(90)90573-D

DO - 10.1016/0888-7543(90)90573-D

M3 - Article

C2 - 2307474

AN - SCOPUS:0025279070

VL - 6

SP - 324

EP - 332

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 2

ER -