The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q

Ann M. Saunders, Michael F Seldin

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

The syntenic relationship of the myotonic dystrophy (DM) gene region on human chromosome 19q and proximal mouse chromosome 7 was examined using an interspecific backcross between C3H/HeJ- gld gld mice and Mus spretus. Segregation analyses were used to order homologs of nine human loci linked were the DM gene. Their order from the centromere was Prkcg, [Apoe, Atpa-2, Ckmm, D19S19h, Ercc-2], Cyp2b, Mag. Lhb. Two other murine loci, D7Rp2 and Ngfg, were also positioned within this interval. Homologs for five human chromosome 11 and 15 loci (Calc, Fes, Hras-1, Igflr, Tyr) were localized within an 18-cM span telomeric to Lhb. Comparison of the gene orders indicates an inversion extending from Prkcg through the interval between Mag and Lhb. This study establishes a detailed map of proximal mouse chromosome 7 that will be useful in identifying and determining whether new human chromosome 19 probes are linked to the DM region.

Original languageEnglish (US)
Pages (from-to)324-332
Number of pages9
JournalGenomics
Volume6
Issue number2
DOIs
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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