The survival impact of the choice of surgical procedure after ipsilateral breast cancer recurrence

Steven L. Chen, Steve R. Martinez

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Many women with breast cancer recurrence previously treated with breast-conservation therapy desire repeat lumpectomies. We hypothesized that women undergoing mastectomy for breast cancer recurrence would show superior survival. Methods: Patients who previously received breast-conservation therapy diagnosed with an ipsilateral breast cancer recurrence between 1988 and 2004 were identified using the Surveillance, Epidemiology, and End Results database. Univariate survival analysis was performed using the Kaplan-Meier method. Cox regression was used for multivariate analysis. Results: Criteria for analysis were met in 747 patients. Of those, 24% underwent lumpectomy. On univariate analysis, patients undergoing lumpectomy had worse overall survival (P = .03). Five-year survival was 67% versus 78% for the lumpectomy and mastectomy groups, respectively. On multivariate analysis, mastectomy remained significantly associated with better survival with a hazard ratio of .5 (P = .003). Conclusions: The use of lumpectomy for ipsilateral breast cancer recurrence previously treated with breast-conservation therapy should generally be discouraged.

Original languageEnglish (US)
Pages (from-to)495-499
Number of pages5
JournalAmerican Journal of Surgery
Volume196
Issue number4
DOIs
StatePublished - Oct 2008

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Segmental Mastectomy
Breast Neoplasms
Recurrence
Survival
Mastectomy
Multivariate Analysis
Survival Analysis
Epidemiology
Databases

Keywords

  • Breast cancer
  • Lumpectomy
  • Mastectomy
  • Prognosis
  • Re-operation
  • Recurrence

ASJC Scopus subject areas

  • Surgery

Cite this

The survival impact of the choice of surgical procedure after ipsilateral breast cancer recurrence. / Chen, Steven L.; Martinez, Steve R.

In: American Journal of Surgery, Vol. 196, No. 4, 10.2008, p. 495-499.

Research output: Contribution to journalArticle

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